Chemico-Biological Interactions

Volume 224, 5 December 2014, Pages 136–141

Evaluation of anticandidal and antioxidant activities of phenolic compounds from Pyrostegia venusta (Ker Gawl.) Miers

• Ana Maria S. Pereira^, , 
• Camila Hernandes, 
• Sarazete I.V. Pereira, 
• Bianca W. Bertoni, 
• Suzelei C. França, 
• Paulo S. Pereira, 
• Silvia H. Taleb-Contini

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doi:10.1016/j.cbi.2014.10.023

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Highlights

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This is the first time that verbascoside and isoverbascoside were isolated from P. venusta.

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The anticandidal activity of the verbascoside isolated from P. venusta was validated.

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P. venusta phytocomplex is more effective than the reference antimicrobials.

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Abstract

We have investigated the in vitro anticandidal and antioxidant activities of phenolic compounds fromPyrostegia venusta flower extracts. We used the HPLC technique to purify the flavonoid (quercetin-3-O-α-l-rhamnopyranosyl-(1→6)-β-d-galactopyranoside) and two phenylpropanoid glycosides (verbascoside and isoverbascoside); we evaluated the antimicrobial activity of the extracts against Candida strains (Candidaalbicans; Candidakrusei ATCC 6258; and the clinical isolate strains of Candida sp. C. albicans, C. krusei, Candidatropicalis, Candidaparapsilosis, and Candidaguilhermondii). The P. venusta flower extracts displayed antimicrobial and antioxidant activities. The semi-purified fraction of the P. venustaflower extract and the phenylpropanoid glycoside verbascoside exhibited activity similar to that of amphotericin B, which denoted that they are potentially applicable as natural antioxidant and anticandidal agents in the pharmaceutical industries.

Keywords

• Cerrado; 
• Bignoniaceae; 
• Verbascoside; 
• Antimicrobial activity; 
• Phytotherapy

Corresponding author. Tel.: +55 16 3603 6727; fax: +55 16 3603 7030.

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