| 1617 | Pocahontas (Rebecca Rolfe) dies of either small pox or pneumonia while in England with her husband, John Rolfe. | |
| 1788 | Almost the entire city of New Orleans, Louisiana, is destroyed by fire. | |
| 1806 | Lewis and Clark begin their trip home after an 8,000 mile trek of the Mississippi basin and the Pacific Coast. | |
| 1928 | President Calvin Coolidge presents the Congressional Medal of Honor to Charles Lindbergh, a captain in the US Army Air Corps Reserve, for making the first solo trans-Atlantic flight. On June 11, 1927, Lindbergh had received the first Distinguished Flying Cross ever awarded. | |
| 1980 | President Jimmy Carter announces to the U.S. Olympic Team that they will not participate in the 1980 Summer Games in Moscow as a boycott against Soviet intervention in Afghanistan. | |
| Born on March 21 | ||
| 1685 | Johann Sebastian Bach, German composer. | |
| 1869 | Florenz Ziegfeld, producer, creator of Ziegfeld Follies. | |