Volume 21, March 2016, Pages 1–9
Highlights
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- Rats consumed dietary fibre (DF) from H. sabdariffa (Hs) and A. tequilana (At).
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- Animals fed Hs alone or combined with At (Mix) had lower body weight and adiposity.
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- Plasma cholesterol and glucose were lower in Hs and Mix groups, and GLP1 was higher.
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- Ground HS calyces in particular provide DF with potential anti-obesity uses.
Abstract
The anti-obesity potential of dietary fibre (DF) from Hibiscus sabdariffa (ground calyces) and Agave tequilana
(agave-fructans) as an additive in the feed of animals subjected to a
high fat diet was examined. Over a 5-week period, the effects of each DF
alone, and in combination, were examined with respect to food intake,
weight gain, adiposity, plasma metabolic profile, appetite regulation
and inflammatory biomarkers in white and brown adipose tissue.
Supplementation with the ground H. sabdariffa calyces was
associated with a reduction in body weight, adiposity, plasma total
cholesterol and glucose. As novel findings, the addition of H. sabdariffa
increased plasma GLP1, reduced proinflammatory cytokines in white
adipose tissue and increased IL6 in brown adipose tissue; it therefore
appears to be a promising source of functional DF. These effects were
partially maintained when H. sabdariffa was supplied in combination with A. tequilana DF and were independent of appetite reduction.
Keywords
- Functional dietary fibre;
- Agave tequilana;
- Hibiscus sabdariffa;
- Obesity;
- GLP1;
- Adipose tissue
Abbreviations
- DF, Dietary Fibre;
- HFD, High Fat Diet;
- StD, Standard Diet;
- Hs, Hibiscus sabdariffa;
- At, Agave tequilana;
- WAT, White Adipose Tissue;
- BAT, Brown Adipose Tissue;
- AST, aspartate transaminase;
- ALT, alanine transaminase;
- GIP, gastric inhibitory polypeptide;
- GLP1, glucagon-like peptide-1;
- PYY, pancreatic peptide;
- SCFA, Short chain fatty acids;
- SD, Standard deviation
- Corresponding
author. Departamento de Cirugía Experimental, Instituto de
Investigación Hospital La Paz (IdiPAZ), Paseo de la Castellana 261,
Madrid 28046, Spain. Tel.:
+34 91 727 7000 ext.42297; fax: +34 91 727 75 24.
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