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Tuesday, 2 February 2016

IN VITRO STUDY OF THE ANTI-INFLAMMATORY ACTIVITY OF SOME MEDICINAL AND EDIBLE PLANTS GROWING IN RUSSIA

Текст научной статьи по специальности «Медицина и здравоохранение»
Научная статья на тему 'IN VITRO STUDY OF THE ANTI-INFLAMMATORY ACTIVITY OF SOME MEDICINAL AND EDIBLE PLANTS GROWING IN RUSSIA' по специальности 'Медицина и здравоохранение'ЧИТАТЬ СТАТЬЮ
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  • ГРНТИ: 76 — Медицина и здравоохранение
  • ВАК РФ: 14.00.00
  • УДK: 61
  • Указанные автором: УДК: 577.19
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Ключевые слова
  • TNF-α ASSAY , 
    •  
  • ANTI-INFLAMMATORY , 
    •  
  • PLANT EXTRACTS , 
    •  
  • PGE 2 ASSAY

Аннотация
научной статьипо медицине и здравоохранению, автор научной работы — Kalinkevich Katerina , Karandashov Vladimir Evgen'evich, Ptitsyn Leonid Romanovich

The effects of the ethanolic extracts of 105 plants used in Russian traditional medicine, 26 vegetables and fruits and 2 mushrooms on the release of tumor necrosis factor α (TNF-α) and prostaglandin E 2 (PGE 2) in lipopolysaccharide (LPS)-stimulated differentiated human acute monocytic leukemia THP-1 cells were studied using TNF-α and PGE 2 assays, respectively. We found that 16 plant extracts inhibited TNF-α production and 15 extracts decreased PGE 2 release in the cells in a concentration-dependent manner. Guilder rose, tansy, shrubby cinquefoil, wintergreen and prince's pine, the last two of which belong to the Pyrolaceae family, notably inhibited the levels of both of the inflammatory mediators.


Научная библиотека КиберЛенинка: http://cyberleninka.ru/article/n/in-vitro-study-of-the-anti-inflammatory-activity-of-some-medicinal-and-edible-plants-growing-in-russia#ixzz3xK1FMacx

Volume 40, Issue 7, December 2014, Pages 752-761

In vitro study of the anti-inflammatory activity of some medicinal and edibleplants growing in Russia  (Article)

Ajinomoto-Genetika Research Institute, 1-st Dorozhny pr. 1-1, Moscow, Russian Federation 

Abstract

The effects of the ethanolic extracts of 105 plants used in Russian traditional medicine, 26 vegetables and fruits and 2 mushrooms on the release of tumor necrosis factor α (TNF-α) and prostaglandin E2 (PGE2) in lipopolysaccharide (LPS)-stimulated differentiated human acute monocytic leukemia THP-1 cells were studied using TNF-α and PGE2 assays, respectively. We found that 16 plant extracts inhibited TNF-α production and 15 extracts decreased PGE2 release in the cells in a concentration-dependent manner. Guilder rose, tansy, shrubby cinquefoil, wintergreen, and prince's pine, the last two of which belong to the Pyrolaceae family, notably inhibited the levels of both of the inflammatory mediators. © 2014 Pleiades Publishing, Ltd.

Author keywords

anti-inflammatory; PGE2 assay; plant extracts; TNF-α assay
ISSN: 10681620 CODEN: RJBCESource Type: Journal Original language: English
DOI: 10.1134/S106816201407005XDocument Type: Article
Publisher: Maik Nauka Publishing / Springer SBM
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