Polyphenols rich fraction from Geoffroea decorticans fruits flour affects key enzymes involved in metabolic syndrome, oxidative stress and inflammatory process (Article)

Food Chemistry

Volume 190, 10 June 2016, Pages 392-402

Costamagna, M.S.^a, 

Zampini, I.C.^a, 

Alberto, M.R.^a, 

Cuello, S.^a, 

Torres, S.^a, 

Pérez, J.^a, 

Quispe, C.^bc, 

Schmeda-Hirschmann, G.^b, 

Isla, M.I.^a 

 

^a  Laboratorio de Investigación de Productos Naturales (LIPRON), Instituto de Química del NOA (INQUINOA-CONICET), Universidad Nacional de Tucumán, San Miguel de Tucumán, Argentina
^b  Laboratorio de Química de Productos Naturales, Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile
^c  Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique, Chile

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Abstract

Geoffroea decorticans (chañar), is widely distributed throughout Northwestern Argentina. Its fruit is consumed as flour, arrope or hydroalcoholic beverage. The chañar fruits flour was obtained and 39 phenolic compounds were tentatively identified by HPLC-MS/MSⁿ. The compounds comprised caffeic acid glycosides, simple phenolics (protocatechuic acid and vanillic acid), a glycoside of vanillic acid, p-coumaric acid and its phenethyl ester as well as free and glycosylated flavonoids. The polyphenols enriched extract with and without gastroduodenal digestion inhibited enzymes associated with metabolic syndrome, including α-amylase, α-glucosidase, lipase and hydroxyl methyl glutaryl CoA reductase. The polyphenolic extract exhibited antioxidant activity by different mechanisms and inhibited the pro-inflammatory enzymes (ciclooxygenase, lipoxygenase and phospholipase A₂). The polyphenolic extract did not showed mutagenic effect by Ames test against Salmonella typhimurium TA98 and TA100 strains. These findings add evidence that chañar fruit flour may be considered a functional food with preventive properties against diseases associated with oxidative stress, inflammatory mediators and metabolic syndrome. © 2015 Elsevier Ltd. All rights reserved.

Author keywords

Anti-inflammatory activity; Antioxidant activity; Chañar flour; Genotoxicity; Geoffroea decorticans; Metabolic syndrome; Polyphenolic compounds

Indexed keywords

Engineering controlled terms: Antioxidants; Enzymes; Fruits; Metabolism; Plants (botany); Salmonella; Sugars

Anti-inflammatory activity; Anti-oxidant activities; Genotoxicities; Geoffroea decorticans; Metabolic syndromes

Engineering main heading: Polyphenolic compounds

EMTREE drug terms: acarbose; acetylsalicylic acid; alpha glucosidase; amylase; caffeic acid; enzyme; flavonoid; gallic acid; hydroxymethylglutaryl coenzyme A reductase; lipoxygenase; naproxen; nimesulide; para coumaric acid; phospholipase A2; plant glycoside; polyphenol derivative; pravastatin; prostaglandin synthase; protocatechuic acid; quercetin; tetrahydrolipstatin; triacylglycerol lipase; vanillic acid

EMTREE medical terms: Ames test; animal experiment; antibacterial activity; antiinflammatory activity; antioxidant activity; Article; bacterial strain; controlled study; digestion; drug determination; duodenum; enzyme inhibition; enzyme metabolism; flour; fractionation; fruit; Geoffroea decorticans; high performance liquid chromatography; hyperglycemia; IC50; inflammation; medicinal plant; metabolic syndrome X; mutagenic activity; nonhuman; oxidative stress; phytochemistry; Salmonella enterica serovar Typhimurium; tandem mass spectrometry

Species Index: Geoffroea decorticans; Salmonella typhimurium

Chemicals and CAS Registry Numbers: acarbose, 56180-94-0; acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; alpha glucosidase, 9001-42-7; amylase, 9000-90-2, 9000-92-4, 9001-19-8; caffeic acid, 27323-69-9, 331-39-5; gallic acid, 149-91-7; hydroxymethylglutaryl coenzyme A reductase, 37250-24-1; lipoxygenase, 9027-17-2, 9029-60-1; naproxen, 22204-53-1, 26159-34-2; nimesulide, 51803-78-2; para coumaric acid, 7400-08-0; phospholipase A2, 9001-84-7; pravastatin, 81093-37-0, 81131-70-6; prostaglandin synthase, 39391-18-9, 59763-19-8, 9055-65-6; protocatechuic acid, 99-50-3; quercetin, 117-39-5; tetrahydrolipstatin, 96829-58-2; triacylglycerol lipase, 9001-62-1; vanillic acid, 121-34-6

ISSN: 03088146 CODEN: FOCHDSource Type: Journal Original language: English

DOI: 10.1016/j.foodchem.2015.05.068Document Type: Article

Publisher: Elsevier Ltd

Funding Details

Acronym; Sponsor: FONDECYT; Fondo Nacional de Desarrollo Científico y Tecnológico
Acronym; Sponsor: MINCyT; Fondo Nacional de Desarrollo Científico y Tecnológico