Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders

Life Sciences

Volume 75, Issue 14, 20 August 2004, Pages 1659-1699

  (Short Survey)

Zhang, Z.-J.^abc 

 

^a  Department of Psychiatry, Uniformed Serv. Univ. Hlth. Sci., Bethesda, MD, United States
^b  Department of Psychiatry, First Hospital, Coll. Med., xi'An Jiaotong U., Shaanxi, China
^c  Department of Psychiatry, Uniformed Serv. Univ. Hlth. Sci., 4301 Jones Bridge Road, 20814, Bethesda, MD, United States 

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Abstract

A search for novel pharmacotherapy from medicinal plants for psychiatric illnesses has progressed significantly in the past decade. This is reflected in the large number of herbal preparations for which psychotherapeutic potential has been evaluated in a variety of animal models. The objective of this review is to provide an overview of herbal extracts and constituents that have significant therapeutic effects in animal models of psychiatric illnesses. Eighty five individual herbs reviewed were classified as anxiolytic, antidepressant, neuroleptic, antidementia, or anti-substance abuse herbs. The full scientific name of each herb, herbal part used, active constituent, extract, dose range and route, animal model, possible mechanisms of action, and pertinent references are presented via synoptic tables. The herbal mixtures were also mentioned. A considerable number of herbal constituents whose behavioral effects and pharmacological actions have been well characterized may be good candidates for further investigations that may ultimately result in clinical use. The investigation of a large portion of the herbal extracts and herbal mixtures is in its infancy. Herbal remedies that have demonstrable psychotherapeutic activities have provided a potential to psychiatric pharmaceuticals and deserve increased attention in future studies. © 2004 Elsevier Inc. All rights reserved.

Author keywords

Animal models; Anti-substance abuse; Antidementia; Antidepressant; Anxiolytic; Behavioral effects; Herbal medicines; Neuroleptic

Indexed keywords

EMTREE drug terms: acorus tatarinowii extract; antidepressant agent; anxiolytic agent; apigenin; apocynum venetum extract; areca catechu extract; Astragalus membranaceus extract; Bacopa monnieri extract; baicalein; barakol; chrysin; Clitoria ternatea extract; Curcuma longa extract; euphoria longana extract; evodia rutaecarpa extract; Ginkgo biloba extract; herbaceous agent; honokiol; huperzine A; Hypericum perforatum extract; kava extract; kielmeyera coriacea extract; neuroleptic agent; nootropic agent; polygala tenufolia extract; reticulin; Solanum nigrum extract; sphaeranthus senegalensis extract; unclassified drug; unindexed drug; Withania somnifera extract

EMTREE medical terms: abies pindrow; Alzheimer disease; amaryllidaceous; anxiety disorder; Apocynum venetum; azadirachta india; Bacopa monnieri; betel nut; biota orientalis; cardiovascular disease; cassia siamea; cecropia glaziouri; celastrus panicualtus; Chinese medicine; cissampelos sympodialis; clitoria rugosa; cognitive defect; dementia; depression; dose response; drug activity; drug effect; drug mechanism; euphoria longana; Eurycoma; ficus platyphylla; galanthus nivalis; Gastrodia elata; Ginkgo biloba; ginseng; gliricidia septum; guava; herbal medicine; hunteria zeylanica; Hypericum perforatum; hypertension; kielmeyera cortiacea; kyllinga brevifolia; leucus lavandualefolia; magnolia officinalis; Matricaria; maze test; medicinal plant; MEDLINE; Melissa officinalis; mental deficiency; mitragyna africanus; nelumo nucifera; Nerium; nonhuman; ocotea duckei; open field test; Piper methysticum; rubus brasiliensis; Salvia miltiorrhiza; schisandrae chinensis; Scutellaria baicalensis; short survey; sickingia williamsii; substance abuse; tilia tomentosa; tranquilizing activity; Withania; Withania somnifera; ziziphus jujube

MeSH: Animals; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Dementia; Disease Models, Animal; Mental Disorders; Phytotherapy; Plant Extracts; Plants, Medicinal; PubMed; Substance-Related Disorders
Medline is the source for the MeSH terms of this document.

Species Index: Animalia

Chemicals and CAS Registry Numbers: apigenin, 520-36-5; baicalein, 491-67-8; chrysin, 12624-02-1, 480-40-0; honokiol, 35354-74-6; huperzine A, 102518-79-6, 92138-20-0;Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Plant Extracts

ISSN: 00243205 CODEN: LIFSASource Type: Journal Original language: English

DOI: 10.1016/j.lfs.2004.04.014 PubMed ID: 15268969Document Type: Short Survey

References (367)

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• 
  1

  Adzu, B., Amos, S., Dzarma, S., Wambebe, C., Gamaniel, K.

  Effect of Zizyphus spina-christi Willd aqueous extract on the central nervous system in mice
  (2002) Journal of Ethnopharmacology, 79 (1), pp. 13-16. Cited 51 times.
  doi: 10.1016/S0378-8741(01)00348-8
  

  • View at Publisher
• 
  2

  Ahn, S.-H., Jeon, S.-H., Tsuruo, T., Shim, C.-K., Chung, S.-J.

  Pharmacokinetic Characterization of Dehydroevodiamine in the Rat Brain
  (2004) Journal of Pharmaceutical Sciences, 93 (2), pp. 283-292. Cited 13 times.
  doi: 10.1002/jps.10546
  

  • View at Publisher
• 
  3

  Ai, J., Wang, X., Nielsen, M.

  Honokiol and magnolol selectively interact with GABAA receptor subtypes in vitro
  (2001) Pharmacology, 63 (1), pp. 34-41. Cited 40 times.
  doi: 10.1159/000056110
  

  • View at Publisher
• 
  4

  Aji, B.M., Onyeyili, P.A., Osunkwo, U.A.

  The central nervous effects of Mitragyna africanus (Willd) stembark extract in rats
  (2001) Journal of Ethnopharmacology, 77 (2-3), pp. 143-149. Cited 8 times.
  doi: 10.1016/S0378-8741(01)00267-7
  

  • View at Publisher
• 
  5

  Akhondzadeh, S., Noroozian, M., Mohammadi, M., Ohadinia, S., Jamshidi, A.H., Khani, M.

  Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: A double blind, randomised, placebo controlled trial
  (2003) Journal of Neurology Neurosurgery and Psychiatry, 74 (7), pp. 863-866. Cited 99 times.
  doi: 10.1136/jnnp.74.7.863
  

  • View at Publisher
• 
  6

  Ali, B.H., Alqarawi, A.A., Bashir, A.K., Tanira, M.O.

  Antioxidant action of extract of the traditional medicinal plant Rhazya stricta decne. in rats
  (2000) Phytotherapy Research, 14 (6), pp. 469-471. Cited 8 times.
  doi: 10.1002/1099-1573(200009)14:6<469::AID-PTR612>3.0.CO;2-W
  

  • View at Publisher
• 
  7

  Ali, B.H., Bashir, A.K., Tanira, M.O.M.

  The effect of Rhazya stricta Decne, a traditional medicinal plant, on the forced swimming test in rats
  (1998) Pharmacology Biochemistry and Behavior, 59 (2), pp. 547-550. Cited 17 times.
  www.elsevier.com/locate/pharmbiochembeh
  doi: 10.1016/S0091-3057(97)00470-X
  

  • View at Publisher
• 
  8

  Ali, B.H., Tanira, M.O.M., Bashir, A.K., Al-Qarawi, A.A.

  Effect of Rhazya stricta Decne on monoamine oxidase and cholinesterase activity and brain biogenic amine levels in rats
  (2000) Journal of Pharmacy and Pharmacology, 52 (10), pp. 1297-1300. Cited 4 times.
  

  • View at Publisher
• 
  9

  Almeida, R.N., Navarro, D.S., De Assis, T.S., De Medeiros, I.A., Thomas, G.

  Antidepressant effect of an ethanolic extract of the leaves of Cissampelos sympodialis in rats and mice
  (1998) Journal of Ethnopharmacology, 63 (3), pp. 247-252. Cited 25 times.
  doi: 10.1016/S0378-8741(98)00086-5
  

  • View at Publisher
• 
  10

  Amagaya, S., Umeda, S.H.M., Ogihara, Y.

  Effects of Shosaikoto, an oriental herbal medicinal mixture, on age-induced amnesia in rats
  (1990) Journal of Ethnopharmacology, 28 (3), pp. 349-356. Cited 5 times.
  doi: 10.1016/0378-8741(90)90086-9
  

  • View at Publisher
• 
  11

  Amos, S., Adzu, B., Binda, L., Wambebe, C., Gamaniel, K.

  Neuropharmacological effect of the aqueous extract of Sphaeranthus senegalensis in mice
  (2001) Journal of Ethnopharmacology, 78 (1), pp. 33-37. Cited 25 times.
  doi: 10.1016/S0378-8741(01)00316-6
  

  • View at Publisher
• 
  12

  Amos, S., Binda, L., Akah, P., Wambebe, C., Gamaniel, K.

  Central inhibitory activity of the aqueous extract of Crinum giganteum
  (2003) Fitoterapia, 74 (1-2), pp. 23-28. Cited 9 times.
  doi: 10.1016/S0367-326X(02)00287-3
  

  • View at Publisher
• 
  13

  Amos, S., Binda, L., Vongtau, H., Chindo, B., Abbah, J., Sambo, N., Odin, E.M., (...), Gamaniel, K.

  Sedative effects of the methanolic leaf extract of Newbouldia laevis in mice and rats
  (2002) Bollettino Chimico Farmaceutico, 141 (6), pp. 471-475. Cited 4 times.
  
• 
  14

  Amos, S., Kolawole, E., Akah, P., Wambebe, C., Gamaniel, K.

  Behavioral effects of the aqueous extract of Guiera senegalensis in mice and rats
  (2001) Phytomedicine, 8 (5), pp. 356-361. Cited 50 times.
  

  • View at Publisher
• 
  15

  An, S.-J., Park, S.-K., Hwang, I.K., Choi, S.Y., Kim, S.K., Kwon, O.-S., Jung, S.J., (...), Kang, T.-C.

  Gastrodin decreases immunoreactivities of γ-aminobutyric acid shunt enzymes in the hippocampus of seizure-sensitive gerbils
  (2003) Journal of Neuroscience Research, 71 (4), pp. 534-543. Cited 47 times.
  doi: 10.1002/jnr.10502
  

  • View at Publisher
• 
  16

  Ang, H.H., Cheang, H.S.

  Studies on the anxiolytic activity of Eurycoma longifolia Jack roots in mice
  (1999) Japanese Journal of Pharmacology, 79 (4), pp. 497-500. Cited 29 times.
  wwwsoc.nacsis.ac.jp/tjps/jjp
  doi: 10.1254/jjp.79.497
  

  • View at Publisher
• 
  17

  Assis, T.S., Almeida, R.N., Barbosa-Filho, J.M., Medeiros, I.A.

  CNS pharmacological effects of the total alkaloidal fraction from Albizia inopinata leaves
  (2001) Fitoterapia, 72 (2), pp. 124-130. Cited 9 times.
  doi: 10.1016/S0367-326X(00)00268-9
  

  • View at Publisher
• 
  18

  Audi, E.A., Otobone, F., Martins, J.V.C., Cortez, D.A.G.

  Preliminary evaluation of Kielmeyera coriacea leaves extract on the central nervous system
  (2002) Fitoterapia, 73 (6), pp. 517-519. Cited 19 times.
  doi: 10.1016/S0367-326X(02)00183-1
  

  • View at Publisher
• 
  19

  Bai, D.L., Tang, X.C., He, X.C.

  Huperzine A, A potential therapeutic agent for treatment of Alzheimer's disease
  (2000) Current Medicinal Chemistry, 7 (3), pp. 355-374. Cited 165 times.
  

  • View at Publisher
• 
  20

  Barkats, M., Venault, P., Christen, Y., Cohen-Salmon, C.

  Effect of long-term treatment with EGb 761 on age-dependent structural changes in the hippocampi of three inbred mouse strains
  (1994) Life Sciences, 56 (4), pp. 213-222. Cited 42 times.
  doi: 10.1016/0024-3205(94)00915-5
  

  • View at Publisher
• 
  21

  Batatinha, M.J.M., de Souza-Spinosa, H., Bernardi, M.M.

  Croton zehntneri: possible central nervous system effects of the essential oil in rodents
  (1995) Journal of Ethnopharmacology, 45 (1), pp. 53-57. Cited 32 times.
  doi: 10.1016/0378-8741(94)01195-6
  

  • View at Publisher
• 
  22

  Batey, R., Cao, Q.

  Effects of CH-100, a Chinese herbal medicine, on acute concanavalin A- mediated hepatitis in control and alcohol-fed rats
  (2000) Alcoholism: Clinical and Experimental Research, 24 (6), pp. 852-858. Cited 9 times.
  
• 
  23

  Beaubrun, G., Gray, G.E.

  A review of herbal medicines for psychiatric disorders
  (2000) Psychiatric Services, 51 (9), pp. 1130-1134. Cited 103 times.
  doi: 10.1176/appi.ps.51.9.1130
  

  • View at Publisher
• 
  24

  Beijamini, V., Andreatini, R.

  Effects of Hypericum perforatum and paroxetine in the mouse defense test battery
  (2003) Pharmacology Biochemistry and Behavior, 74 (4), pp. 1015-1024. Cited 6 times.
  doi: 10.1016/S0091-3057(03)00034-0
  

  • View at Publisher
• 
  25

  Beijamini, V., Andreatini, R.

  Effects of Hypericum perforatum and paroxetine on rat performance in the elevated T-maze
  (2003) Pharmacological Research, 48 (2), pp. 199-207. Cited 25 times.
  doi: 10.1016/S1043-6618(03)00097-5
  

  • View at Publisher
• 
  26

  Béjar, E., Malone, M.H.

  Pharmacological and chemical screening of Byrsonima crassifolia, a medicinal tree from Mexico. Part I
  (1993) Journal of Ethnopharmacology, 39 (2), pp. 141-158. Cited 23 times.
  doi: 10.1016/0378-8741(93)90029-5
  

  • View at Publisher
• 
  27

  Benishin, C.G., Lee, R., Wang, L.C., Liu, H.J.

  Effects of ginsenoside RB1 on central cholinergic metabolism
  (1991) Pharmacology, 42 (4), pp. 223-229. Cited 86 times.
  doi: 10.1159/000138801
  

  • View at Publisher
• 
  28

  Bhattacharya, S.K., Bhattacharya, A., Kumar, A., Ghosal, S.

  Antioxidant activity of Bacopa monniera in rat frontal cortex, striatum and hippocampus
  (2000) Phytotherapy Research, 14 (3), pp. 174-179. Cited 177 times.
  doi: 10.1002/(SICI)1099-1573(200005)14:3<174::AID-PTR624>3.0.CO;2-O
  

  • View at Publisher
• 
  29

  Bhattacharya, S.K., Bhattacharya, A., Sairam, K., Ghosal, S.

  Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: An experimental study
  (2000) Phytomedicine, 7 (6), pp. 463-469. Cited 119 times.
  

  • View at Publisher
• 
  30

  Bhattacharya, S.K., Bhattacharya, D., Sairam, K., Ghosal, S.

  Effect of Withania somnifera glycowithanolides on a rat model of tardive dyskinesia
  (2002) Phytomedicine, 9 (2), pp. 167-170. Cited 43 times.
  

  • View at Publisher
• 
  31

  Bhattacharya, S.K., Muruganandam, A.V.

  Adaptogenic activity of Withania somnifera: An experimental study using a rat model of chronic stress
  (2003) Pharmacology Biochemistry and Behavior, 75 (3), pp. 547-555. Cited 136 times.
  doi: 10.1016/S0091-3057(03)00110-2
  

  • View at Publisher
• 
  32

  Bilia, A.R., Gallori, S., Vincieri, F.F.

  Kava-kava and anxiety: Growing knowledge about the efficacy and safety
  (2002) Life Sciences, 70 (22), pp. 2581-2597. Cited 78 times.
  doi: 10.1016/S0024-3205(02)01555-2
  

  • View at Publisher
• 
  33

  Birks, J., Grimley, E.V., Van Dongen, M.

  Ginkgo biloba for cognitive impairment and dementia.
  (2002) Cochrane database of systematic reviews (Online), (4), p. CD003120. Cited 45 times.
  
• 
  34

  Bopaiah, C.P., Pradhan, N., Venkataram, B.S.

  Pharmacological study on antidepressant activity of 50% ethanol extract of a formulated ayurvedic product in rats
  (2000) Journal of Ethnopharmacology, 72 (3), pp. 411-419. Cited 7 times.
  doi: 10.1016/S0378-8741(00)00232-4
  

  • View at Publisher
• 
  35

  Bores, G.M., Huger, F.P., Petko, W., Mutlib, A.E., Camacho, F., Rush, D.K., Selk, D.E., (...), Vargas, H.M.

  Pharmacological evaluation of novel Alzheimer's disease therapeutics: Acetylcholinesterase inhibitors related to galanthamine
  (1996) Journal of Pharmacology and Experimental Therapeutics, 277 (2), pp. 728-738. Cited 187 times.
  
• 
  36

  Butterweck, V.

  Mechanism of action of St John's wort in depression: What is known?
  (2003) CNS Drugs, 17 (8), pp. 539-562. Cited 188 times.
  

  • View at Publisher
• 
  37

  Butterweck, V., Christoffel, V., Nahrstedt, A., Petereit, F., Spengler, B., Winterhoff, H.

  Step by step removal of hyperforin and hypericin: Activity profile of different Hypericum preparations in behavioral models
  (2003) Life Sciences, 73 (5), pp. 627-639. Cited 75 times.
  doi: 10.1016/S0024-3205(03)00314-X
  

  • View at Publisher
• 
  38

  Butterweck, V., Jürgenliemk, G., Nahrstedt, A., Winterhoff, H.

  Flavonoids from Hypericum perforatum show antidepressant activity in the forced swimming test
  (2000) Planta Medica, 66 (1), pp. 3-6. Cited 262 times.
  doi: 10.1055/s-2000-11119
  

  • View at Publisher
• 
  39

  Butterweck, V., Simbrey, K., Seo, S., Sasaki, T., Nishibe, S.

  Long-term effects of an Apocynum venetum extract on brain monoamine levels and β-AR density in rats
  (2003) Pharmacology Biochemistry and Behavior, 75 (3), pp. 557-564. Cited 36 times.
  doi: 10.1016/S0091-3057(03)00118-7
  

  • View at Publisher
• 
  40

  Butterweck, V., Wall, A., Lieflander-Wulf, U., Winterhoff, H., Nahrstedt, A.

  Effects of the total extract and fractions of Hypericum perforatum in animal assays for antidepressant activity
  (1997) Pharmacopsychiatry, 30 (SUPPL.), pp. 117-124. Cited 184 times.
  

  • View at Publisher
• 
  41

  Butterweck, V., Nishibe, S., Sasaki, T., Uchida, M.

  Antidepressant effects of apocynum venetum leaves in a forced swimming test
  (2001) Biological and Pharmaceutical Bulletin, 24 (7), pp. 848-851. Cited 69 times.
  doi: 10.1248/bpb.24.848
  

  • View at Publisher
• 
  42

  Calapai, G., Crupi, A., Firenzuoli, F., Inferrera, G., Ciliberto, G., Parisi, A., De Sarro, G., (...), Caputi, A.P.

  Interleukin-6 involvement in antidepressant action of Hypericum perforatum
  (2001) Pharmacopsychiatry, 34 (SUPPL. 1), pp. S8-S10. Cited 29 times.
  
• 
  43

  Calapai, G., Crupi, A., Firenzuoli, F., Inferrera, G., Squadrito, F., Parisi, A., De Sarro, G., (...), Caputi, A.

  Serotonin, norepinephrine and dopamine involvement in the antidepressant action of hypericum perforatum
  (2001) Pharmacopsychiatry, 34 (2), pp. 45-49. Cited 60 times.
  doi: 10.1055/s-2001-15180
  

  • View at Publisher
• 
  44

  Camps, P., Cusack, B., Mallender, W.D., El Achab, R., Morral, J., Muñoz-Torrero, D., Rosenberry, T.L.

  Huprine X is a novel high-affinity inhibitor of acetylcholinesterase that is of interest for treatment of Alzheimer's disease
  (2000) Molecular Pharmacology, 57 (2), pp. 409-417. Cited 82 times.
  

  • View at Publisher
• 
  45

  Cao, Y., Chu, Q., Ye, J.

  Determination of hydroxyl radical by capillary electrophoresis and studies on hydroxyl radical scavenging activities of Chinese herbs
  (2003) Analytical and Bioanalytical Chemistry, 376 (5), pp. 691-695. Cited 36 times.
  doi: 10.1007/s00216-003-1961-7
  

  • View at Publisher
• 
  46

  Capasso, A., Aquino, R., De Simone, F., Sorrentino, L.

  Neuropharmacological effects of extracts from Sickingia williamsii
  (1996) Journal of Pharmacy and Pharmacology, 48 (6), pp. 592-595. Cited 8 times.
  

  • View at Publisher
• 
  47

  Carlini, E.A.

  Plants and the central nervous system
  (2003) Pharmacology Biochemistry and Behavior, 75 (3), pp. 501-512. Cited 194 times.
  doi: 10.1016/S0091-3057(03)00112-6
  

  • View at Publisher
• 
  48

  Cervo, L., Rozio, M., Ekalle-Soppo, C.B., Guiso, G., Morazzoni, P., Caccia, S.

  Role of hyperforin in the antidepressant-like activity of Hypericum perforatum extracts
  (2002) Psychopharmacology, 164 (4), pp. 423-428. Cited 69 times.
  doi: 10.1007/s00213-002-1229-5
  

  • View at Publisher
• 
  49

  Chatterjee, S.S., Bhattacharya, S.K., Wonnemann, M., Singer, A., Müller, W.E.

  Hyperforin as a possible antidepressant component of hypericum extracts
  (1998) Life Sciences, 63 (6), pp. 499-510. Cited 355 times.
  doi: 10.1016/S0024-3205(98)00299-9
  

  • View at Publisher
• 
  50

  Chattopadhyay, D., Arunachalam, G., Mandal, S.C., Bhadra, R., Mandal, A.B.

  CNS activity of the methanol extract of Mallotus peltatus (Geist) Muell Arg. leaf: An ethnomedicine of Onge
  (2003) Journal of Ethnopharmacology, 85 (1), pp. 99-105. Cited 20 times.
  doi: 10.1016/S0378-8741(02)00379-3
  

  • View at Publisher
• 
  51

  Chau, D.T., Rada, P., Kosloff, R.A., Taylor, J.L., Hoebel, B.G.

  Nucleus accumbens muscarinic receptors in the control of behavioral depression: Antidepressant-like effects of local M₁ antagonist in the Porsolt swim test
  (2001) Neuroscience, 104 (3), pp. 791-798. Cited 45 times.
  doi: 10.1016/S0306-4522(01)00133-6
  

  • View at Publisher
• 
  52

  Cheng, D.H., Ren, H., Tang, X.C.

  Huperzine A, a novel promising acetylcholinesterase inhibitor
  (1997) NeuroReport, 8 (1), pp. 97-101. Cited 84 times.
  

  • View at Publisher
• 
  53

  Cheng, J., Kuang, P., Wu, W., Zhang, F.

  Effects of transient forebrain ischemia and radix salviae miltiorrhizae (RSM) on extracellular levels of monoamine neurotransmitters and metabolites in the gerbil striatum - An in vivo microdialysis study
  (1999) Journal of Traditional Chinese Medicine, 19 (2), pp. 135-140. Cited 9 times.
  
• 
  54

  Chindo, B.A., Amos, S., Odutola, A.A., Vongtau, H.O., Abbah, J., Wambebe, C., Gamaniel, K.S.

  Central nervous system activity of the methanol extract of Ficus platyphylla stem bark
  (2003) Journal of Ethnopharmacology, 85 (1), pp. 131-137. Cited 20 times.
  doi: 10.1016/S0378-8741(02)00376-8
  

  • View at Publisher
• 
  55

  Cho, J., Joo, N.E., Kong, J.-Y., Jeong, D.-Y., Lee, K.D., Kang, B.-S.

  Inhibition of excitotoxic neuronal death by methanol extract of Acori graminei rhizoma in cultured rat cortical neurons
  (2000) Journal of Ethnopharmacology, 73 (1-2), pp. 31-37. Cited 43 times.
  doi: 10.1016/S0378-8741(00)00262-2
  

  • View at Publisher
• 
  56

  Cho, J., Ho Kim, Y., Kong, J.-Y., Ha Yang, C., Gook Park, C.

  Protection of cultured rat cortical neurons from excitotoxicity by asarone, a major essential oil component in the rhizomes of Acorus gramineus
  (2002) Life Sciences, 71 (5), pp. 591-599. Cited 83 times.
  doi: 10.1016/S0024-3205(02)01729-0
  

  • View at Publisher
• 
  57

  Cho, J., Kong, J.-Y., Jeong, D.-Y., Lee, K.D., Lee, D.-U., Kang, B.-S.

  NMDA recepter-mediated neuroprotection by essential oils from the rhizomes of Acorus gramineus
  (2001) Life Sciences, 68 (13), pp. 1567-1573. Cited 47 times.
  doi: 10.1016/S0024-3205(01)00944-4
  

  • View at Publisher
• 
  58

  Chopin, P., Briley, M.

  Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in rats
  (1992) Psychopharmacology, 106 (1), pp. 26-30. Cited 88 times.
  doi: 10.1007/BF02253584
  

  • View at Publisher
• 
  59

  Chu, N.-S.

  Effects of Betel chewing on the central and autonomic nervous systems
  (2001) Journal of Biomedical Science, 8 (3), pp. 229-236. Cited 105 times.
  doi: 10.1159/000054038
  

  • View at Publisher
• 
  60

  Chu, N.-S.

  Neurological aspects of areca and betel chewing
  (2002) Addiction Biology, 7 (1), pp. 111-114. Cited 63 times.
  doi: 10.1080/13556210120091473
  

  • View at Publisher
• 
  61

  Chung, I.-W., Kim, Y.-S., Ahn, J.-S., Lee, H.-S., Chen, G., Manji, H.K., Potter, W.Z., (...), Pickar, D.

  Pharmacologic profile of natural products used to treat psychotic illnesses
  (1995) Psychopharmacology Bulletin, 31 (1), pp. 139-145. Cited 9 times.
  
• 
  62

  Chung, I.-W., Moore, N.A., Oh, W.-K., O'Neill, M.F., Ahn, J.-S., Park, J.-B., Kang, U.G., (...), Kim, Y.S.

  Behavioural pharmacology of polygalasaponins indicates potential antipsychotic efficacy
  (2002) Pharmacology Biochemistry and Behavior, 71 (1-2), pp. 191-195. Cited 52 times.
  doi: 10.1016/S0091-3057(01)00648-7
  

  • View at Publisher
• 
  63

  Churchill, J.D., Gerson, J.L., Hinton, K.A., Mifek, J.L., Walter, M.J., Winslow, C.L., Deyo, R.A.

  The nootropic properties of ginseng saponin Rb₁ are linked to effects on anxiety
  (2002) Integrative Physiological and Behavioral Science, 37 (3), pp. 178-187. Cited 13 times.
  

  • View at Publisher
• 
  64

  Cohen-Salmon, Ch., Venault, P., Martin, B., Raffalli-Sébille, M.-J., Barkats, M., Clostre, F., Pardon, M.-C., (...), Chapouthier, G.

  Effects of Ginkgo biloba extract (EGb 761) on learning and possible actions on aging
  (1997) Journal of Physiology Paris, 91 (6), pp. 291-300. Cited 48 times.
  doi: 10.1016/S0928-4257(97)82409-6
  

  • View at Publisher
• 
  65

  Coleta, M., Campos, M.G., Cotrim, M.D., Pronça da Cunha, A.

  Comparative evaluation of Melissa officinalis L., Tilia europaea L., Passiflora edulis Sims. and Hypericum perforatum L. in the elevated plus maze anxiety test
  (2001) Pharmacopsychiatry, 34 (SUPPL. 1), pp. S20-S21. Cited 39 times.
  
• 
  66

  Cui, C., Yang, M., Yao, Z., Cao, B., Luo, Z., Xu, Y., Chen, Y.

  Antidepressant active constituents in the roots of Morinda officinalis How
  (1995) Zhongguo zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 20 (1), pp. 36-39, 62. Cited 8 times.
  
• 
  67

  Dajas, F., Rivera, F., Blasina, F., Arredondo, F., Echeverry, C., Lafon, L., Morquio, A., (...), Heizen, H.

  Cell culture protection and in vivo neuroprotective capacity of flavonoids
  (2003) Neurotoxicity Research, 5 (6), pp. 425-432. Cited 100 times.
  doi: 10.1007/BF03033172
  

  • View at Publisher
• 
  68

  Dar, A., Khatoon, S., Rahman, G., Atta-Ur-Rahman

  Anti-depressant activities of Areca catechu fruit extract
  (1997) Phytomedicine, 4 (1), pp. 41-45. Cited 16 times.
  

  • View at Publisher
• 
  69

  Dar, A., Khatoon, S.

  Antidepressant effects of ethanol extract of Areca catechu in rodents
  (1997) Phytotherapy Research, 11 (2), pp. 174-176. Cited 18 times.
  doi: 10.1002/(SICI)1099-1573(199703)11:2<174::AID-PTR65>3.0.CO;2-B
  

  • View at Publisher
• 
  70

  Dar, A., Khatoon, S.

  Behavioral and biochemical studies of dichloromethane fraction from the Areca catechu nut
  (2000) Pharmacology Biochemistry and Behavior, 65 (1), pp. 1-6. Cited 58 times.
  doi: 10.1016/S0091-3057(99)00179-3
  

  • View at Publisher
• 
  71

  Das, A., Shanker, G., Nath, C., Pal, R., Singh, S., Singh, H.K.

  A comparative study in rodents of standardized extracts of Bacopa monniera and Ginkgo biloba - Anticholinesterase and cognitive enhancing activities
  (2002) Pharmacology Biochemistry and Behavior, 73 (4), pp. 893-900. Cited 158 times.
  doi: 10.1016/S0091-3057(02)00940-1
  

  • View at Publisher
• 
  72

  Daudt, R., Von Poser, G.L., Neves, G., Rates, S.M.K.

  Screening for the antidepressant activity of some species of Hypericum from South Brazil
  (2000) Phytotherapy Research, 14 (5), pp. 344-346. Cited 40 times.
  doi: 10.1002/1099-1573(200008)14:5<344::AID-PTR586>3.0.CO;2-3
  

  • View at Publisher
• 
  73

  De Andrés, A.I., Gómez-Serranillos, M.P., Iglesias, I., Villar, A.M.

  Effects of extract of Cistus populifolius L. on the central nervous system
  (1999) Phytotherapy Research, 13 (7), pp. 575-579. Cited 9 times.
  doi: 10.1002/(SICI)1099-1573(199911)13:7<575::AID-PTR506>3.0.CO;2-W
  

  • View at Publisher
• 
  74

  De Feo, V., Faro, C.

  Pharmacological effects of extracts from Valeriana adscendens Trel. II. Effects on GABA uptake and amino acids
  (2003) Phytotherapy Research, 17 (6), pp. 661-664. Cited 19 times.
  doi: 10.1002/ptr.1225
  

  • View at Publisher
• 
  75

  De Smet, P.A.G.M.

  The role of plant-derived drugs and herbal medicines in healthcare
  (1997) Drugs, 54 (6), pp. 801-840. Cited 170 times.
  

  • View at Publisher
• 
  76

  Desai, A.K., Grossberg, G.T.

  Herbals and botanicals in geriatric psychiatry
  (2003) American Journal of Geriatric Psychiatry, 11 (5), pp. 498-506. Cited 15 times.
  http://www.sciencedirect.com.scopeesprx.elsevier.com/science/journal/10647481
  doi: 10.1097/00019442-200309000-00004
  

  • View at Publisher
• 
  77

  Deutsch, S.I., Rosse, R.B., Billingslea, E.N., Bellack, A.S., Mastropaolo, J.

  Modulation of MK-801-elicited mouse popping behavior by galantamine is complex and dose-dependent
  (2003) Life Sciences, 73 (18), pp. 2355-2361. Cited 13 times.
  doi: 10.1016/S0024-3205(03)00642-8
  

  • View at Publisher
• 
  78

  Dhara, A.K., Pal, S., Nag Chaudhuri, A.K.

  Psychopharmacological studies on Tragia involucrata root extract
  (2002) Phytotherapy Research, 16 (4), pp. 326-330. Cited 10 times.
  doi: 10.1002/ptr.891
  

  • View at Publisher
• 
  79

  Dhawan, K., Dhawan, S., Chhabra, S.

  Attenuation of benzodiazepine dependence in mice by a tri-substituted benzoflavone moiety of Passiflora incarnata Linneaus: A non-habit forming anxiolytic
  (2003) Journal of Pharmacy and Pharmaceutical Sciences, 6 (2), pp. 215-222. Cited 42 times.
  http://www.ualberta.ca/~csps/JPPS6(2)/K.Dhawan/anxiolytic.pdf
  

  • View at Publisher
• 
  80

  Dhawan, K., Kumar, S., Sharma, A.

  Anti-anxiety studies on extracts of Passiflora incarnata Linneaus
  (2001) Journal of Ethnopharmacology, 78 (2-3), pp. 165-170. Cited 99 times.
  doi: 10.1016/S0378-8741(01)00339-7
  

  • View at Publisher

  Zhang, Z.-J.; Department of Psychiatry, Uniformed Serv. Univ. Hlth. Sci., 4301 Jones Bridge Road, 20814, Bethesda, MD, United States; email:zzhang1@usuhs.mil
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