The influence of certain plant substances and their chemopreventive activity in ovarian cancer.
Abstract
A
steadily growing number of studies have confirmed the beneficial
effects of plant-derived substances (preparations) on the effectiveness
of pharmacotherapy for ovarian cancer. A prior or parallel application
of plant-derived substances and chemotherapy could be the way to
strengthen the classic pharmacological treatment. Our paper presents
several plant-derived substances with proven antiproliferative
activities, in which phenolic and flavonoid bioactive compounds
dominate, with particular emphasis on ovarian cancer cells. We are of
the opinion that our paper will contribute to better understanding of
the molecular basis for the positive interaction effect of concomitant
application of the abovementioned plant substances with certain
cytostatics. Also, this work may increase the number of preclinical in
vivo experiments using these and other phenolic, flavonoid-rich plant
substances to better understand their efficacy and safety and, in the
future, to initiate clinical trials in this field.
