Volume 28, Issue 19, 1 October 2014, Pages 1583-1590
Urgineaglyceride A: A new monoacylglycerol from the Egyptian Drimia maritima bulbs (Article)
a
Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt
b Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
c Suez Canal University Hospital, Suez Canal University, Ismailia, Egypt
b Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
c Suez Canal University Hospital, Suez Canal University, Ismailia, Egypt
Abstract
One new compound,
(2S)-1-O-(Z)-tetracos-6-enoate glycerol (1) named urgineaglyceride A,
along with six known compounds, 3,5,7,3',5'-pentahydroxydihydroflavonol
(2), stigmasterol (3), (25S)-5β-furostane-3β-22α-26-triol (4),
scillaridin A (5), (2S)-(+)-2-hydroxynaringenin-4'-O-β-d-glucopyranoside
(6) and quercetin-3'-O-β-d-glucopyranoside (7), were isolated from the
EtOAc fraction of Drimia maritima
(L.) Stearn bulbs. Their structures were secured based on their IR, UV,
1D and 2D NMR data, in addition to HR-MS data and comparison with the
literature data. The isolated compounds were evaluated for their in
vitro growth inhibitory activity against A549 non-small cell lung cancer
(NSCLC), U373 glioblastoma (GBM) and PC-3 prostate cancer cell lines.
Compounds 2 and 3 displayed variable activities against the tested
cancer cell lines. Compound 2 was a selective inhibitor of the NSCLC
cell line with an IC50 of 2.3 μM, whereas 3 was selective against GBM with IC50 of 0.5 M and against PC-3 with 2.0 μM. © 2014 Taylor & Francis.
Author keywords
Drimia maritima; in vitro growth inhibitory activity; monoacylglycerol; urgineaglyceride A
Indexed keywords
EMTREE drug terms: 2 hydroxynaringenin 4' o beta dextro
glucopyranoside; 3,5,7,3',5' pentahydroxydihydroflavonol; 5beta
furostane 3beta 22alpha 26 triol; antineoplastic agent;
monoacylglycerol; quercetin 3' o beta dextro glucopyranoside;
scillaridin a; squill; stigmasterol; unclassified drug; urgineaglyceride
a; antineoplastic agent; monoacylglycerol; monosaccharide; quercetin;
quercetin-3'-O-beta-D-glucopyranoside; urgineaglyceride A; (2) 2
hydroxynaringenin 4' o beta dextro glucopyranoside; (25) 5beta furostane
3beta 22alpha 26 triol; 3,5,7,3',5' pentahydroxydihydroflavonol;
antineoplastic agent; cisplatin; quercetin 3'o beta dextro
glucopyranoside; scillaridin a; stigmasterol; urgineaglyceride a
EMTREE medical terms: Article; cancer inhibition;
comparative study; drug activity; drug cytotoxicity; drug isolation;
drug structure; glioblastoma cell line; human; human cell; IC50; in
vitro study; infrared spectroscopy; non small cell lung cancer;
nonhuman; nuclear magnetic resonance; plant bulb; prostate cancer cell
line; ultraviolet spectroscopy; analogs and derivatives; chemical
structure; chemistry; drug screening; Egypt; isolation and purification;
Liliaceae; male; plant root; controlled study; Drimia maritima; lung cancer cell line; mass spectrometry; medicinal plant; structure activity relation; ultraviolet radiation
MeSH: Antineoplastic Agents, Phytogenic; Drug Screening
Assays, Antitumor; Egypt; Humans; Inhibitory Concentration 50;
Liliaceae; Male; Molecular Structure; Monoglycerides; Monosaccharides;
Nuclear Magnetic Resonance, Biomolecular; Plant Roots; Quercetin
Medline is the source for the MeSH terms of this document.
Medline is the source for the MeSH terms of this document.
Chemicals and CAS Registry Numbers: stigmasterol,
83-48-7; quercetin, 117-39-5; cisplatin, 15663-27-1, 26035-31-4,
96081-74-2;Antineoplastic Agents, Phytogenic; Monoglycerides;
Monosaccharides; Quercetin; quercetin-3'-O-beta-D-glucopyranoside;
urgineaglyceride A
