Evid Based Complement Alternat Med. 2015;2015:145140. doi: 10.1155/2015/145140. Epub 2015 Sep 21.
Ozarowski M1, Thiem B2, Mikolajczak PL3, Piasecka A4, Kachlicki P4, Szulc M5, Kaminska E5, Bogacz A6, Kujawski R7, Bartkowiak-Wieczorek J6, Kujawska M8, Jodynis-Liebert J8, Budzianowski J2, Kędziora I2, Seremak-Mrozikiewicz A9, Czerny B10, Bobkiewicz-Kozłowska T5.
Author information
- 1Department of Pharmaceutical Botany and Plant Biotechnology, Poznan University of Medical Sciences, Sw. Marii Magdaleny 14, 61-861 Poznan, Poland ; Department of Pharmacology and Phytochemistry, Institute of Natural Fibers and Medicinal Plants, Libelta 27, 61-707 Poznan, Poland.
- 2Department of Pharmaceutical Botany and Plant Biotechnology, Poznan University of Medical Sciences, Sw. Marii Magdaleny 14, 61-861 Poznan, Poland.
- 3Department of Pharmacology and Phytochemistry, Institute of Natural Fibers and Medicinal Plants, Libelta 27, 61-707 Poznan, Poland ; Department of Pharmacology, University of Medical Sciences, Rokietnicka 5a, 60-806 Poznan, Poland.
- 4Department of Pathogen Genetics and Plant Resistance, Metabolomics Team, Institute of Plant Genetics of the Polish Academy of Science, Strzeszynska 34, 60-479 Poznan, Poland.
- 5Department of Pharmacology, University of Medical Sciences, Rokietnicka 5a, 60-806 Poznan, Poland.
- 6Department of Pharmacology and Phytochemistry, Institute of Natural Fibers and Medicinal Plants, Libelta 27, 61-707 Poznan, Poland ; Laboratory of Experimental Pharmacogenetics, Department of Clinical Pharmacy and Biopharmacy, University of Medical Sciences, Sw. Marii Magdaleny 14, 61-861 Poznan, Poland.
- 7Department of Pharmacology and Phytochemistry, Institute of Natural Fibers and Medicinal Plants, Libelta 27, 61-707 Poznan, Poland.
- 8Department of Toxicology, Poznan University of Medical Sciences, Dojazd 30, 60-631 Poznan, Poland.
- 9Department of Pharmacology and Phytochemistry, Institute of Natural Fibers and Medicinal Plants, Libelta 27, 61-707 Poznan, Poland ; Division of Perinatology and Women's Diseases, Poznan University of Medical Sciences, Polna 33, 60-535 Poznan, Poland ; Laboratory of Molecular Biology, Poznan University of Medical Sciences, Polna 33, 60-535 Poznan, Poland.
- 10Department of Pharmacology and Phytochemistry, Institute of Natural Fibers and Medicinal Plants, Libelta 27, 61-707 Poznan, Poland ; Department of General Pharmacology and Pharmacoeconomics, Pomeranian Medical University, Zolnierska 48, 70-204 Szczecin, Poland ; Department of Stem Cells and Regenerative Medicine, Institute of Natural Fibres and Medicinal Plants, Libelta 27, 61-707 Poznan, Poland.
Abstract
Eryngium
planum L. (EP) is as a rare medicinal plant with a lot of potentials as
pharmaceutical crops. The aim of our study was to assess the effect of
subchronic (28-fold) administration of a 70% ethanol extract of EP roots
(200 mg/kg, p.o.) on behavioral and cognitive responses in Wistar rats
linked with acetylcholinesterase (AChE), butyrylcholinesterase (BuChE),
and beta-secretase (BACE-1) mRNA levels and AChE and BuChE activities in
the hippocampus and frontal cortex. On the last day of experiment,
30 min after the last dose of EP or Huperzine A (HU), scopolamine (SC)
was given at a dose of 0.5 mg/kg b.w. intraperitoneally. The results of a
passive avoidance test showed an improvement in long-term memory
produced by the EP extract in both scopolamine-induced rats and control
group. EP caused an insignificant inhibition of AChE and BuChE
activities in the frontal cortex and the hippocampus. EP decreased mRNA
AChE, BuChE, and BACE-1 levels, especially in the cortex. Our results
suggest that the EP extract led to the improvement of the long-term
memory in rats coupled with total saponin content. The mechanism of EP
action is probably complicated, since HPLC-MS analysis showed 64
chemical compounds (phenolics, saponins) in the extract of EP roots.
- PMID:
- 26483842
- [PubMed]
- PMCID:
- PMC4592897
