Volume 53, Issue 3, 2014, Pages 831-842
a
Department of Biochemistry, Orenburg State Medical Academy, Sovetskaya St., 6, 460014 Orenburg, Russian Federation
b Department of Pathologic Anatomy, Orenburg State Medical Academy, Sovetskaya St., 6, 460014 Orenburg, Russian Federation
c Laboratory of Cellular Symbiosis, Institute of Cellular and Intracellular Symbiosis, Ural Branch of Russian Academy of Sciences, Pionerskaya St., 11, 460000 Orenburg, Russian Federation
b Department of Pathologic Anatomy, Orenburg State Medical Academy, Sovetskaya St., 6, 460014 Orenburg, Russian Federation
c Laboratory of Cellular Symbiosis, Institute of Cellular and Intracellular Symbiosis, Ural Branch of Russian Academy of Sciences, Pionerskaya St., 11, 460000 Orenburg, Russian Federation
Abstract
Purpose: The primary
objective of this study is to investigate the content of biologically
active compounds producing an antioxidant effect in Plantago maxima and
their influence on main mechanisms of dietary obesity development.
Methods: Biologically active compounds in P. maxima were tested using
paper chromatography. In in vivo experiment, high-fat-fed Wistar rats
obtained P. maxima water extract for 3 months. Morphometric parameters,
weight gain, serum adipokines, and cytokines, as well as oxidative
stress biomarkers in rats' tissues were evaluated. Gut microflora was
also examined. Results: Plantago maxima leaves used in the experiment
contained significant amount of flavonoids, iridoids, phenol carboxylic
acids, and tannins and ascorbic acid. Our in vivo experiment data
demonstrate that P. maxima water extract prevents excessive adiposity in
a diet-induced model. P. maxima consumption reduced serum leptin
(twofold), macrophage chemoattractant protein-1 (sevenfold),
tumor-necrosis factor-α (25 %), and interleukine-6 (26 %) levels. P.
maxima water extract decreased adipose tissue oxidative stress
biomarkers in rats fed a high-fat diet. In addition, increased bacterial
growth in the diet-induced obesity model was reversed by the P. maxima
extract treatment. Conclusion: Plantago maxima water extract possessed
antiadipogenic, antidiabetic, antiinflammatory, antioxidant activity,
and normalized gut microflora in a rat model of diet-induced excessive
adiposity due to a high content of biologically active compounds. © 2013
Springer-Verlag Berlin Heidelberg.
Author keywords
Endocrine dysfunction; Excessive adiposity; Inflammation; Oxidative stress; Phytochemicals; Plantago maxima
Indexed keywords
EMTREE drug terms: apigenin; ascorbic acid; biological
marker; carboxylic acid; flavonoid; interleukin 6; iridoid; leptin;
luteolin; luteolin 7 glucoside; macrophage chemoattractant protein 1;
membrane protein; phenol; plant
extract; Plantago maxima extract; tannin derivative; tumor necrosis
factor alpha; unclassified drug; water; adipocytokine; antiobesity
agent; antioxidant; biological marker; cytokine; plant extract
EMTREE medical terms: adipose tissue; animal
experiment; animal model; animal tissue; antidiabetic activity;
antiinflammatory activity; antioxidant activity; article; bacterial
growth; controlled study; female; in vivo study; intestine flora; lipid
diet; medicinal plant; nonhuman; obesity; oxidative stress; paper chromatography; plant
leaf; Plantago; Plantago maxima; rat; weight gain; adipogenesis;
animal; bacterial count; blood; chemistry; colon; diet supplementation;
Gram negative bacterium; growth, development and aging; intraabdominal
fat; isolation and purification; jejunum; metabolism; microbiology;
obesity; pathology; Plantago; Russian Federation; Wistar rat
MeSH: Adipogenesis; Adipokines; Adiposity; Animals;
Anti-Obesity Agents; Antioxidants; Biological Markers; Colon; Colony
Count, Microbial; Cytokines; Dietary Supplements; Female; Gram-Negative
Bacteria; Intra-Abdominal Fat; Jejunum; Obesity; Oxidative Stress; Plant Extracts; Plant Leaves; Plantago; Rats, Wistar; Russia
Medline is the source for the MeSH terms of this document.
Medline is the source for the MeSH terms of this document.
Chemicals and CAS Registry Numbers: apigenin, 520-36-5;
ascorbic acid, 134-03-2, 15421-15-5, 50-81-7; luteolin, 491-70-3;
luteolin 7 glucoside, 5373-11-5; phenol, 108-95-2, 3229-70-7; water,
7732-18-5;Adipokines; Anti-Obesity Agents; Antioxidants; Biological
Markers; Cytokines; Plant Extracts
ISSN: 14366207
CODEN: EJNUFSource Type: Journal
Original language: English
Publisher: Dr. Dietrich Steinkopff Verlag GmbH and Co. KG
