Colloids Surf B Biointerfaces. 2014 Oct 1;122:767-77. doi: 10.1016/j.colsurfb.2014.08.018. Epub 2014 Aug 22.
David L1, Moldovan B1, Vulcu A2, Olenic L2, Perde-Schrepler M3, Fischer-Fodor E4, Florea A5, Crisan M6, Chiorean I7, Clichici S8, Filip GA9.
Author information
- 1Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University, 11 Arany Janos Street, RO 400028, Cluj-Napoca, Romania.
- 2National Institute for Research and Development of Isotopic and Molecular Technologies, 65-103 Donath Street, RO 400293, Cluj-Napoca, Romania.
- 3"Ion Chiricuta" Oncology Institute, 34-36 Republicii Street, 400015, Cluj-Napoca, Romania. Electronic address: mperde@iocn.ro.
- 4"Ion Chiricuta" Oncology Institute, 34-36 Republicii Street, 400015, Cluj-Napoca, Romania.
- 5Department of Cell and Molecular Biology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 6 Louis Pasteur Street, 400349, Cluj Napoca, Romania.
- 6Histology Department, "Iuliu Hatieganu" University of Medicine and Pharmacy, 13 Emil Isaac Street, 400023, Cluj-Napoca, Romania.
- 7Faculty of Mathematics and Computer Science, Babes-Bolyai University, 1 Kogălniceanu Street, 400084, Cluj-Napoca, Romania.
- 8Physiology Department, "Iuliu Hatieganu" University of Medicine and Pharmacy, 13 Emil Isaac Street, 400023, Cluj Napoca, Romania.
- 9Physiology Department, "Iuliu Hatieganu" University of Medicine and Pharmacy, 13 Emil Isaac Street, 400023, Cluj Napoca, Romania. Electronic address: gabriela.filip@umfcluj.ro.
Abstract
This
research aimed at reporting the synthesis, characterization and
evaluation of the anti-inflammatory effects of some new biomaterials
based on silver nanoparticles and polyphenols rich natural extracts. A
fast and eco-friendly extracellular biosynthesis of silver nanoparticles
(AgNPs), using European black elderberry (Sambucus nigra - SN,
Adoxaceae family) fruit extracts was developed. The phytosynthesized
nanoparticles exhibited an absorbance peak at 426nm, characteristic for
AgNPs and their sizes were ranged from 20 to 80nm. The anti-inflammatory
properties of AgNPs were assessed in vitro on HaCaT cells exposed to
UVB radiation, in vivo on acute inflammation model and in humans on
psoriasis lesions. In vitro, our results demonstrated the
anti-inflammatory effects of functionalized AgNPs by the decrease of
cytokines production induced by UVB irradiation. In vivo, the
pre-administration of AgNPs reduced the edema and cytokines levels in
the paw tissues, early after the induction of inflammation. The present
study also demonstrated the possible use of synthesized AgNPs for the
treatment of psoriasis lesions.
Copyright © 2014 Elsevier B.V. All rights reserved.
Copyright © 2014 Elsevier B.V. All rights reserved.
