Zeaxanthin and ocular health, from bench to bedside

Fitoterapia

Volume 109, March 2016, Pages 58-66

 (Review)

Manikandan, R.^a, 

Thiagarajan, R.^b , 

Goutham, G.^a, 

Arumugam, M.^a, 

Beulaja, M.^c, 

Rastrelli, L.^d, 

Skalicka-Woźniak, K.^e, 

Habtemariam, S.^f, 

Orhan, I.E.^g, 

Nabavi, S.F.^h, 

Nabavi, S.M.^h 

 

^a  Department of Zoology, University of Madras, Guindy Campus, Chennai, India
^b  Department of Biotechnology, School of Chemical and Biotechnology, SASTRA University, Thanjavur, India
^c  Department of Biochemistry, Annai Veilankanni's College for Women, Chennai, India 

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Abstract

Cataracts, glaucoma, and age-related macular degeneration are known as major ocular problems which cause blindness among the elderly population worldwide. Oxidative stress plays an important role in both the initiation and progression of ocular problems and with respect to this; dietary antioxidants can serve as a therapeutic strategy for the improvement of ocular health. Zeaxanthin is known as one of the most important and common xanthophyll carotenoids, possessing multiple therapeutic effects such as strong antioxidant and pro-oxidant behaviour as well as anti-inflammatory effects. A growing body of literature shows that zeaxanthin mitigates ocular problems and suppresses oxidative stress in the retinal tissues. This paper aims to critically review the available literature regarding the beneficial effects of zeaxanthin on ocular problems with emphasis on its chemistry, bioavailability, and sources. © 2015 Elsevier B.V. All rights reserved.

Author keywords

Age-related macular degeneration; Cataract; Ocular problems; Oxidative stress; Zeaxanthin

Indexed keywords

EMTREE drug terms: zeaxanthin

EMTREE medical terms: bioavailability; chemistry; disease association; drug effect; eye disease; health; in vitro study; lens epithelium cell; ocular health; ocular tissue; priority journal; retina; Review; senile cataract

Chemicals and CAS Registry Numbers: zeaxanthin, 144-68-3

ISSN: 0367326X CODEN: FTRPASource Type: Journal Original language: English

DOI: 10.1016/j.fitote.2015.12.009Document Type: Review

Publisher: Elsevier

References (94)

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  Nabavi, S.M.; Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Iran; email:Nabavi208@gmail.com
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