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Exploratory Animal and Medical Research, Vol.5, Issue 1, June, 2015
Research Article
COMPARATIVE HAEMOSTATIC EFFICACY OF SUCCULENT
LEAF EXTRACTS AND LATEX OF SOME WOUND HEALING
PLANTS ON FRESH WOUND OF RABBIT
Shibabrata Pattanayak
1*
, Tapan Kumar Mandal
2
, Pratip Kumar Debnath
3
,
Anup Kr. Das
4
, Susanta Kumar Bandyopadhyay
5
.
1
In charge, All India Co-ordinated Research Project on Foot and Mouth Disease, Kolkata Regional
Centre, IAH&VB, Kolkata, West Bengal, India.
2
Professor, Department of Veterinary Pharmacology & Toxicology, West Bengal University of Animal &
Fishery Sciences, 37,Belgachia Road, Kolkata- 700037,West Bengal.
3
Director, Gananath Sen Institute of Ayurveda & Research, Kolkata, West Bengal, India.
4
Professor and Head, Department of Pharmacology, R.G. Kar Medical College, and Hospital, Kolkata,
West Bengal, India.
5
Director of Medical Education and Research, Government of West Bengal, Swastha Bhavan,
Kolkata, West Bengal, India.
* Corresponding author. e - mail: pattanayak1966@gmail.com.
ABSTRACT: Ethnomedicinal report of haemostatic activity of six medicinal plants was validated by
a study of the effect of succulent leaf extract of plant parts on the punch wound of rabbit for the first
time. It was found that the succulent leave extracts of
Artemisia nilagirica
(Clarke),
Barleria lupulina
Lindl.,
Blumea lacera
Dc.,
Croton bonplandianum
Baill,
Glinus lotoides
Lin. and
Mikania scandens
(L)
Willd. can induce haemostasis in fresh wounds as compared to automatic haemostasis (120.00 ±2.91
seconds). The fresh leave extract of
Mikania scandens
took 25.00 ±1.87 seconds for haemostatic activity.
Artemisia nilagirica
(35.00 ± 1.50 seconds),
Barleria lupulina
(30.00 ±2.34 seconds),
Blumea lacera
(38.00 ±1.87 seconds),
Glinus lotoides
(35.00 ±2.29 seconds) are having better action than
Croton
bonplandianum
(leaf extract), which took 40.00 ±2.69 seconds time for haemostasis. The latex collected
from the wounded small branches of living
Croton bonplandianum
plant is having highest efficacy in
causing haemostasis (10.00 ±1.22 seconds), better than the positive control of Tincture Ferric per
Chloride (13.00 ±2.54 seconds). The dermal toxicity study reveals that the application of the fresh
plant extract on the skin of rat failed to produce any detrimental effect. The plant extracts collected
from succulent plant leaves and particularly the latex collected from the living
Croton bonplandianum
Baill. plant can be used as haemostatic agents.
