Volume 10, 22 September 2015, Pages 1505-1520
School of Healthcare Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
Abstract
Background: Polygonum
minus (PM) or locally known in Malaysia, as “kesum” is rich in
micronutrients and natural antioxidants. However, its beneficial effect
on outcome associates with oxidative stress including cognitive function
is yet to be discovered. We assessed the efficacy of PM extract
(LineMinus™) on cognitive function and psychosocial status among
middle-aged women in Klang Valley of Malaysia. Methods: A randomized,
double-blind, placebo-controlled trial among 35 healthy middle-aged
women was performed, and subjects were randomized to receive either 250
mg PM or placebo of 100 mg maltodextrin each were taken twice daily for 6
weeks. Subjects were assessed for neuropsychological test, psychosocial
status, and anthropometric at baseline, week 3, and week 6. Biomarkers
were also determined at baseline and week 6. Results: The
supplementation of PM showed significant intervention effect on Digit
Span test (P<0.05) social functioning domain of 36-Item Short Form
Health Survey (P<0.05) among subjects with mood disturbance. While,
among subjects with good mood, PM supplementation improved Wechsler
Abbreviated Scale of Intelligence (WASI) for IQ verbal (P=0.016) and
Full Scale IQ of WASI (P=0.004). There were no adverse effects reported
for the supplementation as indicated using biomarkers, including liver
function and clinical symptoms. Conclusion: Supplementation of PM is
safe to be consumed for 6 weeks, with potential benefits to attention,
short-term memory, improved quality of life, and mood, as well as IQ. ©
2015 Shahar et al.
Author keywords
Cognitive function; P. minus; Phytochemicals; Psychosocial; Quality of life; Women
Indexed keywords
EMTREE drug terms: hemoglobin A1c; lipid; maltodextrin; plant extract; Polygonum minus extract; psychotropic agent; unclassified drug
EMTREE medical terms: absence of side effects; adult;
Article; attention; blood pressure measurement; body height; body
weight; clinical article; CNS vital sign; cognition; comprehensive trail
making test; controlled study; Digit Span test; double blind procedure;
drug effect; drug safety; drug screening; female; human; intelligence
quotient; intervention study; lipid blood level; liver function test;
Malaysia; middle aged; mood disorder; neuropsychological test; oxidative
stress; patient compliance; Polygonum; Polygonum minus; Profile of Mood
States; quality of life; randomized controlled trial; Rey auditory
verbal learning test; Short Form 36; short term memory; social
psychology; trail making test; treatment duration; vital sign; Wechsler
Abbreviated Scale of Intelligence; Wechsler intelligence scale
Chemicals and CAS Registry Numbers: hemoglobin A1c, 62572-11-6; lipid, 66455-18-3; maltodextrin, 9050-36-6
Drug tradename: lineminus, Biotropics Malaysia Berhad, Malaysia.
Manufacturers:Drug manufacturer: Biotropics Malaysia Berhad, Malaysia.
ISSN: 11769092Source Type: Journal
Original language: English
DOI: 10.2147/CIA.S86411Document Type: Article
Publisher: Dove Medical Press Ltd.
