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Thursday 22 October 2015

The effect of Polygonum minus extract on cognitive and psychosocial parameters according to mood status among middle-aged women: A randomized, double-blind, placebo-controlled study (Article)

Volume 10, 22 September 2015, Pages 1505-1520


School of Healthcare Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia

Abstract

Background: Polygonum minus (PM) or locally known in Malaysia, as “kesum” is rich in micronutrients and natural antioxidants. However, its beneficial effect on outcome associates with oxidative stress including cognitive function is yet to be discovered. We assessed the efficacy of PM extract (LineMinus™) on cognitive function and psychosocial status among middle-aged women in Klang Valley of Malaysia. Methods: A randomized, double-blind, placebo-controlled trial among 35 healthy middle-aged women was performed, and subjects were randomized to receive either 250 mg PM or placebo of 100 mg maltodextrin each were taken twice daily for 6 weeks. Subjects were assessed for neuropsychological test, psychosocial status, and anthropometric at baseline, week 3, and week 6. Biomarkers were also determined at baseline and week 6. Results: The supplementation of PM showed significant intervention effect on Digit Span test (P<0.05) social functioning domain of 36-Item Short Form Health Survey (P<0.05) among subjects with mood disturbance. While, among subjects with good mood, PM supplementation improved Wechsler Abbreviated Scale of Intelligence (WASI) for IQ verbal (P=0.016) and Full Scale IQ of WASI (P=0.004). There were no adverse effects reported for the supplementation as indicated using biomarkers, including liver function and clinical symptoms. Conclusion: Supplementation of PM is safe to be consumed for 6 weeks, with potential benefits to attention, short-term memory, improved quality of life, and mood, as well as IQ. © 2015 Shahar et al.

Author keywords

Cognitive function; P. minus; Phytochemicals; Psychosocial; Quality of life; Women

Indexed keywords

EMTREE drug terms: hemoglobin A1c; lipid; maltodextrin; plant extract; Polygonum minus extract; psychotropic agent; unclassified drug
EMTREE medical terms: absence of side effects; adult; Article; attention; blood pressure measurement; body height; body weight; clinical article; CNS vital sign; cognition; comprehensive trail making test; controlled study; Digit Span test; double blind procedure; drug effect; drug safety; drug screening; female; human; intelligence quotient; intervention study; lipid blood level; liver function test; Malaysia; middle aged; mood disorder; neuropsychological test; oxidative stress; patient compliance; Polygonum; Polygonum minus; Profile of Mood States; quality of life; randomized controlled trial; Rey auditory verbal learning test; Short Form 36; short term memory; social psychology; trail making test; treatment duration; vital sign; Wechsler Abbreviated Scale of Intelligence; Wechsler intelligence scale
Chemicals and CAS Registry Numbers: hemoglobin A1c, 62572-11-6; lipid, 66455-18-3; maltodextrin, 9050-36-6
Drug tradename: lineminus, Biotropics Malaysia Berhad, Malaysia.
Manufacturers:Drug manufacturer: Biotropics Malaysia Berhad, Malaysia.
ISSN: 11769092Source Type: Journal Original language: English
DOI: 10.2147/CIA.S86411Document Type: Article
Publisher: Dove Medical Press Ltd.