Nat Prod Commun. 2015 Jun;10(6):929-31.
Abstract
In
this study, we evaluated the anti-inflammatory activity of the soluble
ethyl acetate fraction and chemical components of the stem bark of Passiflora
foetida (Passifloraceae). Ten flavonoids (1-10) were isolated by
various chromatographic techniques, and their structures were determined
based on spectroscopic analyses by using nuclear magnetic resonance
(NMR). Luteolin (2) and chrysoeriol (3) showed the most potent
inhibition of nitric oxide (NO) production in macrophage cell line,
RAW264.7, with half maximal inhibitor concentration (IC50) values of 1.2
and 3.1 μM, respectively. These compounds suppressed lipopolysaccharide
(LPS)-induced inducible NO synthase (iNOS) expression at the
transcription level. Our research indicates that the stem bark of P.
foetida has significant anti-inflammatory properties, suggesting that
its flavonoids may have anti-inflammatory benefits.
