Flavanones of Erythrina livingstoniana with antioxidant properties

Fitoterapia

Volume 108, January 2016, Pages 48–54

• Kibrom Gebreheiwot Bedane^a, b, 
• Souvik Kusari^b, 
• Ishmael B. Masesane^a, 
• Michael Spiteller^b, , ,
• Runner R.T. Majinda^a, , 

• ^a Department of Chemistry, University of Botswana, Private Bag 0022, Gaborone, Botswana
• ^b Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, 44221, Dortmund, Germany

Received 9 September 2015, Revised 11 November 2015, Accepted 13 November 2015, Available online 17 November 2015

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doi:10.1016/j.fitote.2015.11.014

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Abstract

Six new flavanones (1–6), together with six known compounds were isolated fromErythrina livingstoniana. Their structures were elucidated on the basis of NMR data and HRMSⁿ fragmentation pathway and by comparison with literature data. Compounds 5, 7and 8 showed remarkable DPPH free radical scavenging efficacies. The compounds, however, did not demonstrate an anti-inflammatory potential when tested using a PGE₂(prostaglandin E2) competitive enzyme immunoassay. The plausible biosynthetic pathways of the isolated compounds are described.

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Graphical abstract

Keywords

• Erythrina livingstoniana; 
• Fabaceae; 
• Flavanone; 
• Erylivingstone D–I; 
• NMR; 
• HRMSⁿ

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Copyright © 2015 Elsevier B.V. All rights reserved.