Restrição materna de polifenóis e dinâmica ductal fetal na gestação normal: Um ensaio clínico aberto

Arquivos Brasileiros de Cardiologia

Volume 101, Issue 3, September 2013, Pages 217-225

Open Access

Maternal restriction of polyphenols and fetal ductal dynamics in normal pregnancy: An open clinical trial  (Article)

[]

Zielinsky, P. , 

Piccoli Jr., A.L., 

Vian, I., 

Zílio, A.M., 

Naujorks, A.A., 

Nicoloso, L.H., 

Barbisan, C.W., 

Busato, S., 

Lopes, M., 

Klein, C.

 

Instituto de Cardiologia, Fundação Universitária de Cardiologia, Porto Alegre, RS, Brazil 

View references (39)

Abstract

Background: We have recently demonstrated reversal of fetal ductal constriction after dietary maternal restriction of polyphenol-rich foods (PRF), due to its inhibitory action on prostaglandin synthesis.Objective: To test the hyphotesis that normal third trimester fetuses also improve ductus arteriosus dynamics after maternal restriction of polyphenols.Methods: Open clinical trial with 46 fetuses with gestational age (GA) ≥ 28 weeks submitted to 2 Doppler echocardiographic studies with an interval of at least 2 weeks, being the examiners blinded to maternal dietary habits. A validated food frequency questionnaire was applied and a diet based on polyphenol-poor foods (<30mg/100mg) was recommended. A control group of 26 third trimester fetuses was submitted to the same protocol. Statistics used t test for independent samples.Results: Mean GA was 33±2 weeks. Mean daily maternal estimated polyphenol intake (DMPI) was 1277mg, decreasing to 126mg after dietary orientation (p=0.0001). Significant decreases in systolic (SDV) and diastolic (DDV) ductal velocities, and RV/LV diameters ratio, as well as increase in ductal PI were observed [DSV=1.2±0.4m/s (0.7-1.6) to 0.9±0.3m/s (0.6-1.3) (p=0.018); DDV=0.21±0.09m/s (0.15-0.32) to 0.18±0.06m/s (0.11-0.25) (p=0.016); RV/LV ratio =1.3±0.2 (0.9-1.4) to 1.1±0.2 (0.8-1.3) (p=0.004); ductal PI=2.2±0.03 (2.0-2.7) to 2.4±0.4(2.2-2.9) (p=0.04)]. In the control group, with GA of 32±4 weeks, there were no significant differences in DMPI, mean SDV, DDV, PI and RV/LV ratio.Conclusion: The oriented restriction of third trimester maternal ingestion of polyphenol-rich foods for a period of 2 weeks or more improve fetal ductus arteriosus flow dynamics and right ventricular dimensions.

Author keywords

Anti-inflammatory agents; Constriction; Ductus arteriosus; Fetal heart; Polyphenols / pharmacology; Pregnancy; Prostaglandins

Indexed keywords

EMTREE drug terms: polyphenol

EMTREE medical terms: article; clinical trial; controlled study; diet restriction; Doppler echocardiography; ductus arteriosus; female; fetus; fetus heart; food frequency questionnaire; food intake; gestational age; heart ventricle size; human; nutritional assessment; open study; pregnancy; questionnaire; third trimester pregnancy

MeSH: Ductus Arteriosus; Echocardiography, Doppler; Female; Fetus; Food; Food Habits; Humans; Maternal Nutritional Physiological Phenomena; Polyphenols; Pregnancy; Pregnancy Trimester, Third; Prostaglandins; Time Factors
Medline is the source for the MeSH terms of this document.

Chemicals and CAS Registry Numbers: polyphenol, 37331-26-3

ISSN: 0066782X CODEN: ABCAASource Type: Journal Original language: English, Portuguese

DOI: 10.5935/abc.20130166 PubMed ID: 23949325Document Type: Article

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  Zielinsky, P.; Av. Princesa Isabel, 370, Santana. Postal Code 90620-000, Porto Alegre, RS, Brazil; email:zielinsky.pesquisa@gmail.com
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