- a Department of Ophthalmology, Chung Shan Medical University Hospital, Taichung, Taiwan
- b Department of Chinese Medicine, Ministry of Health and Well-being, Taichung Hospital, Taichung, Taiwan
- c School of Nutrition, Chung Shan Medical University, 110, Sec. 1, Jianguo North Road, Taichung, Taiwan
- d School of Optometry, Chung Shan Medical University, 110, Sec. 1, Jianguo North Road, Taichung, Taiwan
- e School of Health Diet and Industry Management, Chung Shan Medical University, 110, Sec. 1, Jianguo North Road, Taichung, Taiwan
- Received 10 January 2016, Revised 25 March 2016, Accepted 4 April 2016, Available online 12 April 2016
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- Retinoprotective effect of lutein complex (LC) was checked in early stage age-related macular degeneration (AMD) subjects.
- Administration of LC significantly improved the concentrations of serum lutein and zeaxanthin.
- Treatment with LC might lower the oxidative stress by enhancing the antioxidant status and thus preclude the incidence of AMD.
Age-related macular degeneration (AMD) is the age-related disease characterized by chronic and progressive degeneration of photoreceptors. The retinoprotective effect of lutein complex (LC) derived from marigold (lutein) and wolfberry (zeaxanthin) was assessed in subjects with early stage AMD (n = 56). Each subject was instructed to take 60 mL of LC beverage for 5 months. Supplementation with LC substantially escalated the concentrations of serum lutein and zeaxanthin as well as the activities of antioxidant enzymes and the levels of total antioxidative capacity, ocular comfort index (OCI) and macular pigment optical density (MPOD) as compared to baseline. Oxidative stress index (total free radicals and TBARS), inflammatory markers, best-corrected visual acuity (BCVA), and interocular pressure (IOP) were concomitantly lowered in subjects when treated with LC for 5 months. Thus, long-term consumption of LC may suppress the oxidative stress by enhancing the antioxidant status and thereby preclude the incidence of AMD.
- Lutein complex;
- Oxidative stress;
- Macular pigment optical density;
- Age-related macular disorder
© 2016 Published by Elsevier Ltd.