Volume 81, Issue 5, July 2010, Pages 336–338
In vitro antifungal activity of phenylheptatriyne from Bidens cernua L. against yeasts
Abstract
In vitro antifungal activity of phenylheptatriyne from Bidens cernua L. (Asteraceae) was studied using broth macrodilution method against 125 strains of yeasts including 104 clinical and other isolates of Candida spp. (C. albicans, C. krusei, C. tropicalis, C. guilliermondii, C. parapsilosis, C. glabrata, C. inconspicua), 16 strains of basidiomycetous yeasts (Cryptococcus neoformans, C. albidus, Trichosporon cutaneum, Rhodotorula glutinis) and five standard reference strains of Candida
species. Phenylheptatriyne has shown significant activity against
investigated strains, and the Minimal Inhibitory Concentrations for Candida spp. were determined as 12.5–50 µg/ml and for basidiomycetous yeasts as 12.5–100 µg/ml.
Keywords
- Bidens cernua;
- Asteraceae;
- Phenylheptatriyne;
- Invitro antifungal activity;
- Candida spp.;
- Basidiomycetous yeasts
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