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CSIR Unit for Research and Development of Information Products “Tapovan”, S.No.113, 114, NCL Estate, Pashan Road, Pune, Maharashtra, India

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Abstract

Toxic plants are found to have potential therapeutic activities. They have been used in the treatment of a number of dis-eases. Recently there is an increasing demand and interest in bioactive natural products from plants for the purpose of their use in herbal medicine. So critical evaluation of their toxicity has become necessary. This article provides the de-tailed toxicity information of the phytochemical constituents from the toxic plant Anagallis arvensis (Family Primula-ceae). The plant is toxic to ruminants but it has great potential to treat diseases like Gout, Leprosy, Epilepsy, Urinary infection etc. The phytochemical constituents isolated from the toxic plant have Antibacterial, Antifungal, Antiviral, An-titumour, Antidiabetic, Antidepressant, Anti-inflammatory and Hepatoprotective activities. Some bioactives are having therapeutic activity, no reported toxicity and were predicted to be less toxic. Many actives from this plant have not been explored for any activity and their toxicity has not been determined. These actives were found to be less toxic through the toxicity prediction tool. This study would be important for exploiting the potential of such actives which may further prove to be promising natural products for medicinal and cosmetic use. © 2016, International Journal of Toxicological and Pharmacological Research. All rights reserved.

Author keywords

Anagallis; Bioactive; Prediction; Primulaceae; Toxicity; Traditional medicine

ISSN: 09755160Source Type: Journal Original language: English

Document Type: Article

Publisher: International Journal of Toxicological and Pharmacological Research

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1
Jothivel, N., Paul, V.I.
Exploitation of acute toxicity of the seeds of Anamirta cocculus (Linn.) as a potential aquaculture management tool to eradicate unwanted fish fauna
(2008) Asian Fisheries Science, 21, pp. 457-467.
2
Balandrin, M.F., Klocke, J.A.
Medicinal, aro-matic, and industrial materials from plants
(1988) Medici-nal and Aromatic Plants I, pp. 3-36. Cited 56 times.
Springer
3
Wahab, S., Hussain, A., Ahmad, P., Rizvi, A.
Cur-rent status of herbal drugs in the development of new-er therapeutics agents
(2013) Int J Pharm Chem Sci, 2, pp. 1462-1473.
4
Riet-Correa, F., Rivero, R., Dutra, F., Timm, C.D., Mendez, M.C., Garland, T., Barr, A.C.
Recently encountered poisonous plants of Rio Grande do Sul and Uruguay
(1998) Toxic plants and other natural toxicants, pp. 1-5.
5
Al-Sultan, S.I., Hussein, Y.A., Hegazy, A.
Toxicity of Anagallis arvensis plant
(2003) Pakistan Journal of Nutri-tion, 2, pp. 116-122.
6
Banerjee, M., Hazra, A., Bharitkar, Y.P., Mondal, N.B.
Insights of Spermicidal Research: An Update
(2015) Journal of Fertilization: In Vitro-IVF-Worldwide.
7
Mohanan, P.V., Devi, K.S.
Toxicological evaluation of sobatum
(1998) Cancer Letters, 127 (1-2), pp. 135-140. Cited 8 times.
doi: 10.1016/S0304-3835(98)00022-6
- View at Publisher
8
Malini, T., Vanithakumari, G.
Antifertility effects of β-sitosterol in male albino rats
(1991) Journal of Ethnopharmacology, 35 (2), pp. 149-153. Cited 46 times.
doi: 10.1016/0378-8741(91)90066-M
- View at Publisher
9
Awad, A.B., Chen, Y.-C., Fink, C.S., Hennessey, T.
β-sitosterol inhibits HT-29 human colon cancer cell growth and alters membrane lipids
(1996) Anticancer Research, 16 (5 A), pp. 2797-2804. Cited 116 times.
10
Choi, S., Kim, K.-W., Choi, J.-S., Han, S.-T., Park, Y.-I., Lee, S.-K., Kim, J.-S., (...), Chung, M.-H.
Angiogenic activity of β-sitosterol in the ischaemia/reperfusion-damaged brain of Mongolian gerbil
(2002) Planta Medica, 68 (4), pp. 330-335. Cited 41 times.
doi: 10.1055/s-2002-26750
- View at Publisher
11
Ivorra, M.D., D'Ocon, M.P., Paya, M., Villar, A.
Antihyperglycemic and insulin-releasing effects of β-sitosterol 3-β-D-glucoside and its aglycone, β-sitosterol
(1988) Archives Internationales de Pharmacodynamie et de Therapie, 296, pp. 224-231. Cited 52 times.
12
Ware, G.W.
(1990) Reviews of Environmental Contamination and Toxicology., p. 112.
Springer New York
13
Pérez-Pastén, R., Martínez-Galero, E., Chamorro-Cevallos, G.
Quercetin and naringenin reduce abnormal development of mouse embryos produced by hydroxyurea
(2010) Journal of Pharmacy and Pharmacology, 62 (8), pp. 1003-1009. Cited 8 times.
doi: 10.1111/j.2042-7158.2010.01118.x
- View at Publisher
14
Bjeldanes, L.F., Chang, G.W.
Mutagenic activity of quercetin and related compounds
(1977) Science, 197 (4303), pp. 577-578. Cited 226 times.
- View at Publisher
15
Jazvinscak Jembrek, M., Cipak Gasparovic, A., Vukovic, L., Vlainic, J., Zarkovic, N., Orsolic, N.
Quercetin supplementation: Insight into the potentially harmful outcomes of neurodegenerative prevention
(2012) Naunyn-Schmiedeberg's archives of pharmacology, pp. 1-3.
16
Afanas'ev, I.B., Dcrozhko, A.I., Brodskii, A.V., Kostyuk, V.A., Potapovitch, A.I.
Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation
(1989) Biochemical Pharmacology, 38 (11), pp. 1763-1769. Cited 669 times.
doi: 10.1016/0006-2952(89)90410-3
- View at Publisher
17
Zhang, M., Swarts, S.G., Yin, L., Liu, C., Tian, Y., Cao, Y., Swarts, M., (...), Ju, S.
Antioxidant properties of quercetin
(2011) Oxygen Transport to Tissue XXXII., pp. 283-289.
Springer US
18
Guardia, T., Rotelli, A.E., Juarez, A.O., Pelzer, L.E.
Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat
(2001) Farmaco, 56 (9), pp. 683-687. Cited 258 times.
doi: 10.1016/S0014-827X(01)01111-9
- View at Publisher
19
Vessal, M., Hemmati, M., Vasei, M.
Antidiabetic effects of quercetin in streptozocin-induced diabetic rats
(2003) Comparative Biochemistry and Physiology - C Toxicology and Pharmacology, 135 (3), pp. 357-364. Cited 251 times.
doi: 10.1016/S1532-0456(03)00140-6
- View at Publisher
20
Sugantha Priya, E., Selvakumar, K., Bavithra, S., Elumalai, P., Arunkumar, R., Raja Singh, P., Brindha Mercy, A., (...), Arunakaran, J.
Anti-cancer activity of quercetin in neuroblastoma: An in vitro approach
(2014) Neurological Sciences, 35 (2), pp. 163-170. Cited 5 times.
doi: 10.1007/s10072-013-1462-1
- View at Publisher
21
Canada, A.T., Watkins, W.D., Nguyen, T.D.
The toxicity of flavonoids to guinea pig enterocytes
(1989) Toxicology and Applied Pharmacology, 99 (2), pp. 357-361. Cited 16 times.
doi: 10.1016/0041-008X(89)90018-5
- View at Publisher
22
Stroheker, T., Chagnon, M.-C., Pinnert, M.-F., Berges, R., Canivenc-Lavier, M.-C.
Estrogenic effects of food wrap packaging xenoestrogens and flavonoids in female Wistar rats: A comparative study
(2003) Reproductive Toxicology, 17 (4), pp. 421-432. Cited 34 times.
doi: 10.1016/S0890-6238(03)00044-3
- View at Publisher
23
Carver, J.H., Carrano, A.V., MacGregor, J.T.
Genetic effects of the flavonols quercetin, kaempferol, and galangin on Chinese hamster ovary cells in vitro
(1983) Mutation Research/Environmental Mutagenesis and Related Subjects, 113 (1), pp. 45-60. Cited 80 times.
doi: 10.1016/0165-1161(83)90240-6
- View at Publisher
24
Wang, Y., Tang, C., Zhang, H.
Hepatoprotective effects of kaempferol 3-O-rutinoside and kaempferol 3-O-glucoside from Carthamus tinctorius L. on CCl₄-induced oxidative liver injury in mice
(2015) Journal of Food and Drug Analysis, 23 (2), pp. 310-317. Cited 5 times.
http://www.elsevier.com/journals/journal-of-food-and-drug-analysis/1021-9498#
doi: 10.1016/j.jfda.2014.10.002
- View at Publisher
25
Lim, Y.-H., Kim, I.-H., Seo, J.-J.
In vitro activity of kaempferol isolated from the Impatiens balsamina alone and in combination with erythromycin or clindamycin against Propionibacterium acnes
(2007) Journal of Microbiology, 45 (5), pp. 473-477. Cited 40 times.
http://www.msk.or.kr/jsp/downloadPDF1.jsp?fileName=45(5)_15.pdf
- View at Publisher
26
Jung, C.H., Lee, J.Y., Park, J.H., Cho, B.J., Sim, S.S., Kim, C.J.
Flavonols attenuate the immediate and late-phase asthmatic responses to aerosolized-ovalbumin exposure in the conscious guinea pig
(2010) Fitoterapia, 81 (7), pp. 803-812. Cited 8 times.
doi: 10.1016/j.fitote.2010.04.011
- View at Publisher
27
Grundmann, O., Nakajima, J.-I., Kamata, K., Seo, S., Butterweck, V.
Kaempferol from the leaves of Apocynum venetum possesses anxiolytic activities in the elevated plus maze test in mice
(2009) Phytomedicine, 16 (4), pp. 295-302. Cited 38 times.
doi: 10.1016/j.phymed.2008.12.020
- View at Publisher
28
Xiao, H.-B., Lu, X.-Y., Sun, Z.-L., Zhang, H.-B.
Kaempferol regulates OPN-CD44 pathway to inhibit the atherogenesis of apolipoprotein E deficient mice
(2011) Toxicology and Applied Pharmacology, 257 (3), pp. 405-411. Cited 11 times.
doi: 10.1016/j.taap.2011.09.024
- View at Publisher
29
HARRISSON, J.W., SELTZER, B.W., MARTIN, E.W.
The spectrophotometric examination and acute toxicity of rutins obtained from Fagopyrum esculentum (buckwheat) and Sophora japonica.
(1950) Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 39 (10), pp. 556-559. Cited 3 times.
- View at Publisher
30
Pfeifer, K., Mehnert, W.H., Hülsmann, W.
Comparative animal experimental studies on the concretion-forming effect of diverse Rutin preparations
(1970) Deutsche Gesundheitswesen, 25 (9), pp. 386-391. Cited 4 times.
31
Kojima, A., Fujita, H., Sasaki, M.
Mutagenicity of natural antioxidants in the Ames test
(1986) Tokyo-Toritsu Eisei Kenkyusho Kenkyu Nenpo, 37, p. 453.
32
Fernández, S.P., Wasowski, C., Loscalzo, L.M., Granger, R.E., Johnston, G.A.R., Paladini, A.C., Marder, M.
Central nervous system depressant action of flavonoid glycosides
(2006) European Journal of Pharmacology, 539 (3), pp. 168-176. Cited 114 times.
doi: 10.1016/j.ejphar.2006.04.004
- View at Publisher
33
Lapa, F.D.R., Gadotti, V.M., Missau, F.C., Pizzolatti, M.G., Marques, M.C.A., Dafré, A.L., Farina, M., (...), Santos, A.R.S.
Antinociceptive properties of the hydroalcoholic extract and the flavonoid rutin obtained from Polygala paniculata L. in Mice
(2009) Basic and Clinical Pharmacology and Toxicology, 104 (4), pp. 306-315. Cited 30 times.
doi: 10.1111/j.1742-7843.2008.00365.x
- View at Publisher
34
Sattanathan, M.K., Dhanapal, C.K., Umarani, R., Manavalan, R.
Antihyperglycemic effect of rutin supplementation on diabetic mellitus patients
(2011) International journal of research in pharmaceutical and biomedical sciences, 2 (4), p. 1725.
35
Ziaee, A., Zamansoltani, F., Nassiri-Asl, M., Hadigol, T., Ghasemi, M.
Study of the hepatoprotective effects of rutin on acetaminophen and carbon tetrachloride -induced liver injury in rats
(2011) Pharmaceutical Sciences, 17 (1), pp. 35-42. Cited 2 times.
http://pharm-sci.tbzmed.ac.ir/ARCHEIV/1390/Spring/PDF/5-zeaei.pdf
36
Dubey, S., Ganeshpurkar, A., Bansal, D., Dubey, N.
Experimental studies on bioactive potential of rutin
(2013) Chronicles of Young Scientists, 4 (2), p. 153.
37
Panda, S., Jafri, M., Kar, A., Meheta, B.K.
Thyroid inhibitory, antiperoxidative and hypoglycemic effects of stigmasterol isolated from Butea monosperma
(2009) Fitoterapia, 80 (2), pp. 123-126. Cited 83 times.
doi: 10.1016/j.fitote.2008.12.002
- View at Publisher
38
Ammar, S., Edziri, H., Mahjoub, M.A., Chatter, R., Bouraoui, A., Mighri, Z.
Spasmolytic and anti-inflammatory effects of constituents from Hertia cheirifolia
(2009) Phytomedicine, 16 (12), pp. 1156-1161. Cited 11 times.
doi: 10.1016/j.phymed.2009.03.012
- View at Publisher
39
Gomes, A., Saha, A., Chatterjee, I., Chakravarty, A.K.
Viper and cobra venom neutralization by β-sitosterol and stigmasterol isolated from the root extract of Pluchea indica Less. (Asteraceae)
(2007) Phytomedicine, 14 (9), pp. 637-643. Cited 46 times.
doi: 10.1016/j.phymed.2006.12.020
- View at Publisher
40
Ghosh, T., Maity, T.K., Singh, J.
Evaluation of antitumor activity of stigmasterol, a constituent isolated from Bacopa monnieri Linn aerial parts against ehrlich ascites carcinoma in mice
(2011) Oriental Pharmacy & Experimental Medicine, 11 (1), pp. 41-49.
41
Saeed, M.A., Sabir, A.W.
Irritant potential of some constituents from the seeds of Caesalpinia bonducella (L.) Fleming
(2003) Journal of Asian Natural Products Research, 5 (1), pp. 35-41. Cited 11 times.
doi: 10.1080/1028602031000080441
- View at Publisher
42
Aragão, G.F., Carneiro, L.M.V., Junior, A.P.F., Vieira, L.C., Bandeira, P.N., Lemos, T.L.G., Viana, G.S.d.B.
A possible mechanism for anxiolytic and antidepressant effects of alpha- and beta-amyrin from Protium heptaphyllum (Aubl.) March
(2006) Pharmacology Biochemistry and Behavior, 85 (4), pp. 827-834. Cited 44 times.
doi: 10.1016/j.pbb.2006.11.019
- View at Publisher
43
Le Men, J., Buffard, G., Provost, J., Tiberghien, R., Forgacs, P., Lagrange, E., Albert, O., (...), Aurousseau
Re-lation between structure of cucurbitacins and their tox-icity and laxative activity
(1969) Chimica Therapeutica, 4, p. 459.
44
Blaskovich, M.A., Sun, J., Cantor, A., Turkson, J., Jove, R., Sebti, S.M.
Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice
(2003) Cancer Research, 63 (6), pp. 1270-1279. Cited 396 times.
- View at Publisher
45
Krieger, R.
(2001) Handbook of Pesticide Toxicology, Two-Volume Set: Principles and Agents.. Cited 2 times.
Academic Press
46
Li, Z.J., Shin, J.-M., Choi, D.-K., Lim, S.K., Yoon, T.-J., Lee, Y.H., Sohn, K.-C., (...), Lee, J.-H.
Inhibitory effect of cucurbitacin B on imiquimod-induced skin inflammation
(2015) Biochemical and Biophysical Research Communications, 459 (4), pp. 673-678. Cited 2 times.
http://www.sciencedirect.com.scopeesprx.elsevier.com/science/journal/0006291X
doi: 10.1016/j.bbrc.2015.03.001
- View at Publisher
47
Chan, K.T., Meng, F.Y., Li, Q., Ho, C.Y., Lam, T.S., To, Y., Lee, W.H., (...), Toh, M.
Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL-7402 human hepatocellular carcinoma cells and is effective via oral administration
(2010) Cancer Letters, 294 (1), pp. 118-124. Cited 60 times.
doi: 10.1016/j.canlet.2010.01.029
- View at Publisher
48
Abdelwahab, S.I., Hassan, L.E.A., Sirat, H.M., Yagi, S.M.A., Koko, W.S., Mohan, S., Taha, M.M.E., (...), Hadi, A.H.A.
Anti-inflammatory activities of cucurbitacin e isolated from Citrullus lanatus var. citroides: Role of reactive nitrogen species and cyclooxygenase enzyme inhibition
(2011) Fitoterapia, 82 (8), pp. 1190-1197. Cited 22 times.
doi: 10.1016/j.fitote.2011.08.002
- View at Publisher
49
(1982) NIIRDN Drugs in Japan. Ethical Drugs, p. 137.
6^th Edition Edited by Japan Pharmaceutical Information Center 6
50
Teng, B.-s., Lu, Y.-H., Wang, Z.-T., Tao, X.-Y., Wei, D.-Z.
In vitro anti-tumor activity of isorhamnetin isolated from Hippophae rhamnoides L. against BEL-7402 cells
(2006) Pharmacological Research, 54 (3), pp. 186-194. Cited 64 times.
doi: 10.1016/j.phrs.2006.04.007
- View at Publisher
51
Zhou, C.C., Sun, X.B., Liu, J.Y., Luo, S.Q., Lu, C.Y.
Anti-inflammatory effect of alpha-spinasterol
(1985) Acta Pharmaceutica Sinica, 20 (4), pp. 257-261. Cited 6 times.
52
Freitas, C.S., Baggio, C.H., Dos Santos, A.C., Mayer, B., Twardowschy, A., Luiz, A.P., Marcon, R., (...), Santos, A.R.S.
Antinociceptive properties of the hydroalcoholic extract, fractions and compounds obtained from the aerial parts of Baccharis illinita DC in Mice
(2009) Basic and Clinical Pharmacology and Toxicology, 104 (4), pp. 285-292. Cited 10 times.
doi: 10.1111/j.1742-7843.2008.00367.x
- View at Publisher
53
Singh, B., Sahu, P.M., Lohiya, R.K., Sharma, M.K., Singh, H.L., Singh, S.
Anti-inflammatory activity of alkanoids and triterpenoids from Trichodesma amplexicaule Roth.
(2006) Phytomedicine, 13 (3), pp. 152-156. Cited 13 times.
doi: 10.1016/j.phymed.2004.06.018
- View at Publisher
54
Lee, T.H., Jung, M., Bang, M.-H., Chung, D.K., Kim, J.
Inhibitory effects of a spinasterol glycoside on lipopolysaccharide-induced production of nitric oxide and proinflammatory cytokines via down-regulating MAP kinase pathways and NF-κB activation in RAW264.7 macrophage cells
(2012) International Immunopharmacology, 13 (3), pp. 264-270. Cited 21 times.
doi: 10.1016/j.intimp.2012.05.005
- View at Publisher
55
Takahashi, N., Yoshida, Y., Sugiura, T., Matsuno, K., Fujino, A., Yamashita, U.
Cucurbitacin D isolated from Trichosanthes kirilowii induces apoptosis in human hepatocellular carcinoma cells in vitro
(2009) International Immunopharmacology, 9 (4), pp. 508-513. Cited 24 times.
doi: 10.1016/j.intimp.2009.01.006
- View at Publisher
56
Liu, K., Xing, H., Zhang, S., Liu, S.M., Fung, M.C.
Cucurbitacin D induces fetal hemoglobin synthesis in K562 cells and human hematopoietic progenitors through activation of p38 pathway and stabilization of the γ-globin mRNA
(2010) Blood Cells, Molecules, and Diseases, 45 (4), pp. 269-275. Cited 10 times.
doi: 10.1016/j.bcmd.2010.09.004
- View at Publisher
57
Song, Y., Ding, N., Kanazawa, T., Yamashita, U., Yoshida, Y.
Cucurbitacin D is a new inflammasome activator in macrophages
(2013) International Immunopharmacology, 17 (4), pp. 1044-1050. Cited 5 times.
doi: 10.1016/j.intimp.2013.10.003
- View at Publisher

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Friday, 1 July 2016

Evaluation of potential toxicity of bioactives of anagallis arvensis- A toxic plant

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References (57)

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