Potentially effective natural drugs in treatment for the most common rheumatic disorder: osteoarthritis

Rheumatology International

Volume 35, Issue 5, 1 May 2015, Pages 799-814

Farzaei, M.H.^ab, 

Farzaei, F.^c, 

Gooshe, M.^de, 

Abbasabadi, Z.^b, 

Rezaei, N.^fghi, 

Abdolghaffari, A.H.^jk 

 

^a  Department of Traditional Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
^b  Kermanshah University of Medical Sciences, Kermanshah, Iran
^c  College of Veterinary Medicine, Kermanshah Razi University, Kermanshah, Iran 

View additional affiliations

View references (98)

Abstract

Osteoarthritis (OA) is a chronic condition in which imbalance between anabolic and catabolic mediators occurs leading to the destruction of homeostasis of articular cartilage. The current drugs in the management of OA can just alleviate symptoms. Hence, the research tendency toward exploration of novel sources has been grown up in order to achieve safe and efficacious drugs. Meanwhile, various components exist as novel natural drugs that may possess favorable properties for the management of OA. This review focuses on the most efficacious medicinal plants and their phytochemical agents, which have been consumed for the management of OA. Moreover, evaluation of their efficacy and molecular mechanisms of action are discussed based on numerous modern experimental investigations. More research is needed to develop therapeutic agents with disease-modifying properties to treat OA. © 2014, Springer-Verlag Berlin Heidelberg.

Author keywords

Inflammation; Medicinal plant; Osteoarthritis; Oxidative stress; Pain; Pro-inflammatory cytokine

ISSN: 01728172 CODEN: RHINDSource Type: Journal Original language: English

DOI: 10.1007/s00296-014-3175-z PubMed ID: 25398454Document Type: Review

Publisher: Springer Verlag

References (98)

View in search results format

• Page
 
• • Export |
  • Print |
  • E-mail |
  • Create bibliography

• 
  1

  Brooks, P.M.

  Impact of osteoarthritis on individuals and society: How much disability? Social consequences and health economic implications
  (2002) Current Opinion in Rheumatology, 14 (5), pp. 573-577. Cited 142 times.
  doi: 10.1097/00002281-200209000-00017
  

  • View at Publisher
• 
  2

  Goldring, M.B., Goldring, S.R.

  Osteoarthritis
  (2007) Journal of Cellular Physiology, 213 (3), pp. 626-634. Cited 536 times.
  doi: 10.1002/jcp.21258
  

  • View at Publisher
• 
  3

  Lee, A.S., Ellman, M.B., Yan, D., Kroin, J.S., Cole, B.J., van Wijnen, A.J., Im, H.-J.

  A current review of molecular mechanisms regarding osteoarthritis and pain
  (2013) Gene, 527 (2), pp. 440-447. Cited 63 times.
  doi: 10.1016/j.gene.2013.05.069
  

  • View at Publisher
• 
  4

  Wood, A.M., Brock, T.M., Heil, K., Holmes, R., Weusten, A.
  A review on the management of hip and knee osteoarthritis
  (2013) Int J Chron Dis, p. 2013.
  

  •  
• 
  5

  Spector, T.D.

  Epidemiology of the rheumatic diseases
  (1993) Current Opinion in Rheumatology, 5 (2), pp. 132-137. Cited 19 times.
  

  • View at Publisher
• 
  6

  Hunter, D.J., McDougall, J.J., Keefe, F.J.

  The Symptoms of Osteoarthritis and the Genesis of Pain
  (2008) Rheumatic Disease Clinics of North America, 34 (3), pp. 623-643. Cited 76 times.
  doi: 10.1016/j.rdc.2008.05.004
  

  • View at Publisher
• 
  7

  Sellam, J., Berenbaum, F.

  The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis
  (2010) Nature Reviews Rheumatology, 6 (11), pp. 625-635. Cited 219 times.
  doi: 10.1038/nrrheum.2010.159
  

  • View at Publisher
• 
  8

  Houard, X., Goldring, M.B., Berenbaum, F.

  Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis
  (2013) Current Rheumatology Reports, 15 (11), art. no. 375. Cited 39 times.
  doi: 10.1007/s11926-013-0375-6
  

  • View at Publisher
• 
  9

  Gardner, G.C.

  Inflammatory arthritis in the era of the biologics
  (2005) Clinical and Applied Immunology Reviews, 5 (1), pp. 19-44. Cited 4 times.
  doi: 10.1016/j.cair.2004.11.001
  

  • View at Publisher
• 
  10

  Goldring, M.B., Otero, M.

  Inflammation in osteoarthritis
  (2011) Current Opinion in Rheumatology, 23 (5), pp. 471-478. Cited 194 times.
  doi: 10.1097/BOR.0b013e328349c2b1
  

  • View at Publisher
• 
  11

  Fernandes, J.C., Martel-Pelletier, J., Pelletier, J.-P.

  The role of cytokines in osteoarthritis pathophysiology
  (2002) Biorheology, 39 (1-2), pp. 237-246. Cited 538 times.
  

  • View at Publisher
• 
  12

  Roughley, P.J.

  The structure and function of cartilage proteoglycans
  (2006) European Cells and Materials, 12 (SUPPL.1), p. 11. Cited 76 times.
  http://www.ecmjournal.org/journal/supplements/vol012supp01/pdf/v012supp01a11.pdf
  

  • View at Publisher
• 
  13

  Huang, K., Wu, L.-D.

  Aggrecanase and Aggrecan degradation in osteoarthritis: A review
  (2008) Journal of International Medical Research, 36 (6), pp. 1149-1160. Cited 56 times.
  http://www.jimronline.net/content/full/2008/88/1039.pdf
  

  • View at Publisher
• 
  14

  Sachs, D., Cunha, F.Q., Poole, S., Ferreira, S.H.

  Tumour necrosis factor-α, interleukin-1β and interleukin-8 induce persistent mechanical nociceptor hypersensitivity
  (2002) Pain, 96 (1-2), pp. 89-97. Cited 95 times.
  doi: 10.1016/S0304-3959(01)00433-X
  

  • View at Publisher
• 
  15

  Rezvanfar, M.A., Shojaei Saadi, H.A., Gooshe, M., Abdolghaffari, A.H., Baeeri, M., Abdollahi, M.

  Ovarian aging-like phenotype in the hyperandrogenism-induced murine model of polycystic ovary
  (2014) Oxidative Medicine and Cellular Longevity, 2014, art. no. 948951. Cited 10 times.
  http://www.landesbioscience.com/journals/oximed
  doi: 10.1155/2014/948951
  

  • View at Publisher
• 
  16

  Ziskoven, C., Jäger, M., Kircher, J., Patzer, T., Bloch, W., Brixius, K., Krauspe, R.

  Physiology and pathophysiology of nitrosative and oxidative stress in osteoarthritic joint destruction
  (2011) Canadian Journal of Physiology and Pharmacology, 89 (7), pp. 455-466. Cited 16 times.
  doi: 10.1139/Y11-055
  

  • View at Publisher
• 
  17

  Ziskoven, C., Jäger, M., Zilkens, C., Bloch, W., Brixius, K., Krauspe, R.
  Oxidative stress in secondary osteoarthritis: from cartilage destruction to clinical presentation?
  (2010) Orthop Rev (Pavia), 23 (2), p. 23.
  

  •  
• 
  18

  Dieppe, P.A., Lohmander, L.S.

  Pathogenesis and management of pain in osteoarthritis
  (2005) Lancet, 365 (9463), pp. 965-973. Cited 397 times.
  doi: 10.1016/S0140-6736(05)71086-2
  

  • View at Publisher
• 
  19

  Lee, Y.C., Nassikas, N.J., Clauw, D.J.

  The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia
  (2010) Arthritis Research and Therapy, 13 (2), art. no. 211. Cited 92 times.
  http://arthritis-research.com/content/13/2/211
  doi: 10.1186/ar3306
  

  • View at Publisher
• 
  20

  Felson, D.T.

  The sources of pain in knee osteoarthritis: Editorial review
  (2005) Current Opinion in Rheumatology, 17 (5), pp. 624-628. Cited 134 times.
  doi: 10.1097/01.bor.0000172800.49120.97
  

  • View at Publisher
• 
  21

  Lee, A.S., Ellman, M.B., Yan, D., Kroin, J.S., Cole, B.J., van Wijnen, A.J., Im, H.-J.

  A current review of molecular mechanisms regarding osteoarthritis and pain
  (2013) Gene, 527 (2), pp. 440-447. Cited 63 times.
  doi: 10.1016/j.gene.2013.05.069
  

  • View at Publisher
• 
  22

  van de Laar, M., Pergolizzi Jr., J.V., Mellinghoff, H.-U., Merchante, I.M., Nalamachu, S., O'Brien, J., Perrot, S., (...), Raffa, R.B.

  Pain treatment in arthritis-related pain: Beyond NSAIDs
  (2012) Open Rheumatology Journal, 6 (1), pp. 320-330. Cited 21 times.
  doi: 10.2174/1874312901206010320
  

  • View at Publisher
• 
  23

  Dray, A., Read, S.J.

  Arthritis and pain. Future targets to control osteoarthritis pain
  (2007) Arthritis Research and Therapy, 9 (3), art. no. 212. Cited 56 times.
  doi: 10.1186/ar2178
  

  • View at Publisher
• 
  24

  Valdes, A.M., Spector, T.D.

  Genetic epidemiology of hip and knee osteoarthritis
  (2011) Nature Reviews Rheumatology, 7 (1), pp. 23-32. Cited 72 times.
  doi: 10.1038/nrrheum.2010.191
  

  • View at Publisher
• 
  25

  Kosek, E., Ordeberg, G.

  Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief
  (2000) Pain, 88 (1), pp. 69-78. Cited 249 times.
  doi: 10.1016/S0304-3959(00)00310-9
  

  • View at Publisher
• 
  26

  Long, L., Soeken, K., Ernst, E.

  Herbal medicines for the treatment of osteoarthritis: A systematic review
  (2001) Rheumatology, 40 (7), pp. 779-793. Cited 81 times.
  

  • View at Publisher
• 
  27

  Farzaei, M.H., Khanavi, M., Moghaddam, G., Dolatshahi, F., Rahimi, R., Shams-Ardekani, M.R., Amin, G., (...), Hajimahmoodi, M.

  Standardization of Tragopogon graminifolius DC. Extract based on phenolic compounds and antioxidant activity
  (2014) Journal of Chemistry, 2014, art. no. 425965. Cited 10 times.
  doi: 10.1155/2014/425965
  

  • View at Publisher
• 
  28

  Benedek, B., Kopp, B., Melzig, M.F.

  Achillea millefolium L. s.l. - Is the anti-inflammatory activity mediated by protease inhibition?
  (2007) Journal of Ethnopharmacology, 113 (2), pp. 312-317. Cited 66 times.
  doi: 10.1016/j.jep.2007.06.014
  

  • View at Publisher
• 
  29

  Zaringhalam, J., Akbari, A., Tekieh, E., Manaheji, H., Rezazadeh, S.

  Achillea santolina reduces serum interlukin-6 level and hyperalgesia during complete Freund's adjuvant-induced inflammation in male Wistar rats
  (2010) Journal of Chinese Integrative Medicine, 8 (12), pp. 1180-1189. Cited 14 times.
  http://www.jcimjournal.com/articles/publishArticles/pdf/2010121497528.pdf
  doi: 10.3736/jcim20101211
  

  • View at Publisher
• 
  30

  Gómez, M.A., Sáenz, M.T., García, M.D., Fernández, M.A.

  Study of the topical anti-inflammatory activity of Achillea ageratum on chronic and acute inflammation models
  (1999) Zeitschrift fur Naturforschung - Section C Journal of Biosciences, 54 (11), pp. 937-941. Cited 38 times.
  

  • View at Publisher
• 
  31

  Elmann, A., Mordechay, S., Erlank, H., Telerman, A., Rindner, M., Ofir, R.

  Anti-Neuroinflammatory effects of the extract of Achillea fragrantissima
  (2011) BMC Complementary and Alternative Medicine, 11, art. no. 98. Cited 21 times.
  http://www.biomedcentral.com/1472-6882/11/98
  doi: 10.1186/1472-6882-11-98
  

  • View at Publisher
• 
  32

  Kim, H., Han, T.-H., Lee, S.-G.

  Anti-inflammatory activity of a water extract of Acorus calamus L. leaves on keratinocyte HaCaT cells
  (2009) Journal of Ethnopharmacology, 122 (1), pp. 149-156. Cited 40 times.
  doi: 10.1016/j.jep.2008.12.011
  

  • View at Publisher
• 
  33

  Khan, M.A.A., Islam, M.T.

  Analgesic and cytotoxic activity of Acorus calamus L., Kigelia pinnata L., Mangifera indica L. and Tabernaemontana divaricata L.
  (2012) Journal of Pharmacy and Bioallied Sciences, 4 (2), pp. 149-154. Cited 3 times.
  doi: 10.4103/0975-7406.94820
  

  • View at Publisher
• 
  34

  Hodge, G., Hodge, S., Han, P.

  Allium sativum (garlic) suppresses leukocyte inflammatory cytokine production in vitro: Potential therapeutic use in the treatment of inflammatory bowel disease
  (2002) Cytometry, 48 (4), pp. 209-215. Cited 86 times.
  doi: 10.1002/cyto.10133
  

  • View at Publisher
• 
  35

  Simin, N., Orcic, D., Cetojevic-Simin, D., Mimica-Dukic, N., Anackov, G., Beara, I., Mitic-Culafic, D., (...), Bozin, B.
  Phenolic profile, antioxidant, anti-inflammatory and cytotoxic activities of small yellow onion (Allium flavum L. subsp
  (2013) flavum
  Alliaceae, LWT-Food Science and Technology:
  

  •  
• 
  36

  Woo, K.W., Moon, E., Park, S.Y., Kim, S.Y., Lee, K.R.

  Flavonoid glycosides from the leaves of Allium victorialis var. platyphyllum and their anti-neuroinflammatory effects
  (2012) Bioorganic and Medicinal Chemistry Letters, 22 (24), pp. 7465-7470. Cited 11 times.
  doi: 10.1016/j.bmcl.2012.10.043
  

  • View at Publisher
• 
  37

  Habeeb, F., Stables, G., Bradbury, F., Nong, S., Cameron, P., Plevin, R., Ferro, V.A.

  The inner gel component of Aloe vera suppresses bacterial-induced pro-inflammatory cytokines from human immune cells
  (2007) Methods, 42 (4), pp. 388-393. Cited 31 times.
  doi: 10.1016/j.ymeth.2007.03.005
  

  • View at Publisher
• 
  38

  Kammoun, M., Miladi, S., Ali, Y.B., Damak, M., Gargouri, Y., Bezzine, S.

  In vitro study of the PLA2 inhibition and antioxidant activities of Aloe vera leaf skin extracts
  (2011) Lipids in Health and Disease, 10, art. no. 30. Cited 6 times.
  doi: 10.1186/1476-511X-10-30
  

  • View at Publisher
• 
  39

  Vijayalakshmi, D., Dhandapani, R., Jayaveni, S., Jithendra, P.S., Rose, C., Mandal, A.B.

  In vitro anti inflammatory activity of Aloe vera by down regulation of MMP-9 in peripheral blood mononuclear cells
  (2012) Journal of Ethnopharmacology, 141 (1), pp. 542-546. Cited 21 times.
  doi: 10.1016/j.jep.2012.02.040
  

  • View at Publisher
• 
  40

  Davis, R.H., Rosenthal, K.Y., Cesario, L.R., Rouw, G.A.

  Processed Aloe vera administered topically inhibits inflammation.
  (1989) Journal of the American Podiatric Medical Association, 79 (8), pp. 395-397. Cited 44 times.
  
• 
  41

  Hage-Sleiman, R., Mroueh, M., Daher, C.F.

  Pharmacological evaluation of aqueous extract of Althaea officinalis flower grown in Lebanon
  (2011) Pharmaceutical Biology, 49 (3), pp. 327-333. Cited 12 times.
  doi: 10.3109/13880209.2010.516754
  

  • View at Publisher
• 
  42

  Wang, D.F., Shang, J.Y., Yu, Q.H.

  Analgesic and anti-inflammatory effects of the flower of Althaea rosea (L.) Cav.
  (1989) Zhongguo zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 14 (1), pp. 46-48, 64. Cited 10 times.
  
• 
  43

  Kim, Y.-J., Shin, Y., Lee, K.H., Kim, T.-J.

  Anethum graveloens flower extracts inhibited a lipopolysaccharide-induced inflammatory response by blocking iNOS expression and NF-κB activity in macrophages
  (2012) Bioscience, Biotechnology and Biochemistry, 76 (6), pp. 1122-1127. Cited 14 times.
  https://www.jstage.jst.go.jp/article/bbb/76/6/76_110950/_pdf
  doi: 10.1271/bbb.110950
  

  • View at Publisher
• 
  44

  Valadi, A., Nasri, S., Abbasi, N., Amin, G.R.

  Antinociceptive and anti-inflammatory effects of hydroalchoholic extract of Anethum graveolens L. seed
  (2010) Journal of Medicinal Plants, 9 (34), pp. 124-130. Cited 7 times.
  
• 
  45

  Fan, A.Y., Lao, L., Zhang, R.X., Zhou, A.N., Wang, L.B., Moudgil, K.D., Lee, D.Y.W., (...), Berman, B.M.

  Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on adjuvant-induced arthritis in lewis rats
  (2005) Journal of Ethnopharmacology, 101 (1-3), pp. 104-109. Cited 43 times.
  doi: 10.1016/j.jep.2005.03.033
  

  • View at Publisher
• 
  46

  Gayathri, B., Manjula, N., Vinaykumar, K.S., Lakshmi, B.S., Balakrishnan, A.

  Pure compound from Boswellia serrata extract exhibits anti-inflammatory property in human PBMCs and mouse macrophages through inhibition of TNFα, IL-1β, NO and MAP kinases
  (2007) International Immunopharmacology, 7 (4), pp. 473-482. Cited 68 times.
  doi: 10.1016/j.intimp.2006.12.003
  

  • View at Publisher
• 
  47

  Kimmatkar, N., Thawani, V., Hingorani, L., Khiyani, R.

  Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee - A randomized double blind placebo controlled trial
  (2003) Phytomedicine, 10 (1), pp. 3-7. Cited 156 times.
  doi: 10.1078/094471103321648593
  

  • View at Publisher
• 
  48

  Danquah, C.A., Woode, E., Boakye-Gyasi, E.

  Anti-arthritic effects of an ethanolic extract of capparis erythrocarpos isert roots in freund's adjuvant-induced arthritis in rats
  (2011) Journal of Pharmacology and Toxicology, 6 (3), pp. 201-217. Cited 4 times.
  http://scialert.net/qredirect.php?doi=jpt.2011.201.217&linkid=pdf
  doi: 10.3923/jpt.2011.201.217
  

  • View at Publisher
• 
  49

  Feng, X., Lu, J., Xin, H., Zhang, L., Wang, Y., Tang, K.

  Anti-arthritic active fraction of Capparis spinosa L. fruits and its chemical constituents
  (2011) Yakugaku Zasshi, 131 (3), pp. 423-429. Cited 11 times.
  http://yakushi.pharm.or.jp/FULL_TEXT/131_3/pdf/423.pdf
  doi: 10.1248/yakushi.131.423
  

  • View at Publisher
• 
  50

  Bektas, N., Arslan, R., Goger, F., Kirimer, N., Ozturk, Y.

  Investigation for anti-inflammatory and anti-thrombotic activities of methanol extract of Capparis ovata buds and fruits
  (2012) Journal of Ethnopharmacology, 142 (1), pp. 48-52. Cited 5 times.
  doi: 10.1016/j.jep.2012.04.011
  

  • View at Publisher
• 
  51

  Arslan, R., Bektas, N., Ozturk, Y.

  Antinociceptive activity of methanol extract of fruits of Capparis ovata in mice
  (2010) Journal of Ethnopharmacology, 131 (1), pp. 28-32. Cited 22 times.
  doi: 10.1016/j.jep.2010.05.060
  

  • View at Publisher
• 
  52

  Lewis, A., Levy, A.

  Anti-inflammatory activities of Cassia alata leaf extract in complete freund's adjuvant arthritis in rats
  (2011) West Indian Medical Journal, 60 (6), pp. 615-621. Cited 5 times.
  http://ojs.mona.uwi.edu/index.php/wimj/article/viewFile/2978/2725
  
• 
  53

  Sreejith, G., Latha, P., Shine, V., Anuja, G., Suja, S., Sini, S., Shyamal, S., (...), Rajasekharan, S.
  Anti-allergic
  (2010) anti-inflammatory and anti-lipidperoxidant effects of Cassia occidentalis Linn
  

  •  
• 
  54

  Nsonde Ntandou, G.F., Banzouzi, J.T., Mbatchi, B., Elion-Itou, R.D.G., Etou-Ossibi, A.W., Ramos, S., Benoit-Vical, F., (...), Ouamba, J.M.

  Analgesic and anti-inflammatory effects of Cassia siamea Lam. stem bark extracts
  (2010) Journal of Ethnopharmacology, 127 (1), pp. 108-111. Cited 33 times.
  doi: 10.1016/j.jep.2009.09.040
  

  • View at Publisher
• 
  55

  Liao, J.-C., Deng, J.-S., Chiu, C.-S., Hou, W.-C., Huang, S.-S., Shie, P.-H., Huang, G.-J.

  Anti-inflammatory activities of Cinnamomum cassia constituents in vitro and in vivo
  (2012) Evidence-based Complementary and Alternative Medicine, 2012, art. no. 429320. Cited 37 times.
  doi: 10.1155/2012/429320
  

  • View at Publisher
• 
  56

  Yu, T., Lee, S., Yang, W.S., Jang, H.-J., Lee, Y.J., Kim, T.W., Kim, S.Y., (...), Cho, J.Y.

  The ability of an ethanol extract of Cinnamomum cassia to inhibit Src and spleen tyrosine kinase activity contributes to its anti-inflammatory action
  (2012) Journal of Ethnopharmacology, 139 (2), pp. 566-573. Cited 18 times.
  doi: 10.1016/j.jep.2011.11.051
  

  • View at Publisher
• 
  57

  Vetal, S., Bodhankar, S.L., Mohan, V., Thakurdesai, P.A.
  Anti-inflammatory and anti-arthritic activity of type-A procyanidine polyphenols from bark of Cinnamomum zeylanicum in rats
  (2013) Food Sci Human Wellness. Cited 10 times.
  

  •  
• 
  58

  Nair, V., Kumar, R., Singh, S., Gupta, Y.K.

  Investigation into the anti-inflammatory and antigranuloma activity of Colchicum luteum baker in experimental models
  (2012) Inflammation, 35 (3), pp. 881-888. Cited 7 times.
  doi: 10.1007/s10753-011-9389-2
  

  • View at Publisher
• 
  59

  Nair, V., Singh, S., Gupta, Y.K.

  Evaluation of the disease modifying activity of colchicum luteum Baker in experimental arthritis
  (2011) Journal of Ethnopharmacology, 133 (2), pp. 303-307. Cited 13 times.
  doi: 10.1016/j.jep.2010.09.027
  

  • View at Publisher
• 
  60

  Su, S., Wang, T., Duan, J.-A., Zhou, W., Hua, Y.-Q., Tang, Y.-P., Yu, L., (...), Qian, D.-W.

  Anti-inflammatory and analgesic activity of different extracts of Commiphora myrrha
  (2011) Journal of Ethnopharmacology, 134 (2), pp. 251-258. Cited 26 times.
  doi: 10.1016/j.jep.2010.12.003
  

  • View at Publisher
• 
  61

  Manjula, N., Gayathri, B., Vinaykumar, K.S., Shankernarayanan, N.P., Vishwakarma, R.A., Balakrishnan, A.

  Inhibition of MAP kinases by crude extract and pure compound isolated from Commiphora mukul leads to down regulation of TNF-α, IL-1β and IL-2
  (2006) International Immunopharmacology, 6 (2), pp. 122-132. Cited 32 times.
  doi: 10.1016/j.intimp.2005.07.001
  

  • View at Publisher
• 
  62

  Makabe, H., Maru, N., Kuwabara, A., Kamo, T., Hirota, M.

  Anti-inflammatory sesquiterpenes from Curcuma zedoaria
  (2006) Natural Product Research, 20 (7), pp. 680-685. Cited 60 times.
  doi: 10.1080/14786410500462900
  

  • View at Publisher
• 
  63

  Kaushik, M.L., Jalalpure, S.S.
  Effect of Curcuma zedoaria Rosc root extracts on behavioral and radiology changes in arthritic rats
  (2011) J Adv Pharm Technol Res, 2 (3), p. 170. Cited 3 times.
  PID: 22171314
  

  •  
• 
  64

  Sodsai, A., Piyachaturawat, P., Sophasan, S., Suksamrarn, A., Vongsakul, M.

  Suppression by Curcuma comosa Roxb. of pro-inflammatory cytokine secretion in phorbol-12-myristate-13-acetate stimulated human mononuclear cells
  (2007) International Immunopharmacology, 7 (4), pp. 524-531. Cited 30 times.
  doi: 10.1016/j.intimp.2006.12.013
  

  • View at Publisher
• 
  65

  Ahmadiani, A., Hosseiny, J., Semnanian, S., Javan, M., Saeedi, F., Kamalinejad, M., Saremi, S.

  Antinociceptive and anti-inflammatory effects of Elaeagnus angustifolia fruit extract
  (2000) Journal of Ethnopharmacology, 72 (1-2), pp. 287-292. Cited 82 times.
  doi: 10.1016/S0378-8741(00)00222-1
  

  • View at Publisher
• 
  66

  Liao, C.-R., Chang, Y.-S., Peng, W.-H., Lai, S.-C., Ho, Y.-L.

  Analgesic and anti-inflammatory activities of the methanol extract of Elaeagnus oldhamii Maxim. in mice
  (2012) American Journal of Chinese Medicine, 40 (3), pp. 581-597. Cited 11 times.
  doi: 10.1142/S0192415X12500449
  

  • View at Publisher
• 
  67

  Huang, N., Rizshsky, L., Hauck, C.C., Nikolau, B.J., Murphy, P.A., Birt, D.F.

  The inhibition of lipopolysaccharide-induced macrophage inflammation by 4 compounds in Hypericum perforatum extract is partially dependent on the activation of SOCS3
  (2012) Phytochemistry, 76, pp. 106-116. Cited 13 times.
  doi: 10.1016/j.phytochem.2011.12.001
  

  • View at Publisher
• 
  68

  Hammer, K.D.P., Yum, M.-Y., Dixon, P.M., Birt, D.F.

  Identification of JAK-STAT pathways as important for the anti-inflammatory activity of a Hypericum perforatum fraction and bioactive constituents in RAW 264.7 mouse macrophages
  (2010) Phytochemistry, 71 (7), pp. 716-725. Cited 11 times.
  doi: 10.1016/j.phytochem.2010.02.006
  

  • View at Publisher
• 
  69

  Süntar, I.P., Akkol, E.K., Yilmazer, D., Baykal, T., Kirmizibekmez, H., Alper, M., Yeşilada, E.

  Investigations on the in vivo wound healing potential of Hypericum perforatum L.
  (2010) Journal of Ethnopharmacology, 127 (2), pp. 468-477. Cited 75 times.
  doi: 10.1016/j.jep.2009.10.011
  

  • View at Publisher
• 
  70

  Sánchez-Mateo, C.C., Bonkanka, C.X., Hernández-Pérez, M., Rabanal, R.M.

  Evaluation of the analgesic and topical anti-inflammatory effects of Hypericum reflexum L. fil.
  (2006) Journal of Ethnopharmacology, 107 (1), pp. 1-6. Cited 66 times.
  doi: 10.1016/j.jep.2006.01.032
  

  • View at Publisher
• 
  71

  Kaithwas, G., Majumdar, D.K.

  Therapeutic effect of Linum usitatissimum (flaxseed/linseed) fixed oil on acute and chronic arthritic models in albino rats
  (2010) Inflammopharmacology, 18 (3), pp. 127-136. Cited 27 times.
  doi: 10.1007/s10787-010-0033-9
  

  • View at Publisher
• 
  72

  Kaithwas, G., Mukherjee, A., Chaurasia, A., Majumdar, D.K.
  Antiinflammatory
  (2011) analgesic and antipyretic activities of Linum usitatissimum L.(flaxseed/linseed) fixed oil
  

  •  
• 
  73

  Abad, A.N.A., Nouri, M.H.K., Gharjanie, A., Tavakoli, F.

  Effect of Matricaria chamomilla Hydroalcoholic Extract on Cisplatin-induced Neuropathy in Mice
  (2011) Chinese Journal of Natural Medicines, 9 (2), pp. 126-131. Cited 11 times.
  doi: 10.3724/SP.J.1009.2011.00126
  

  • View at Publisher
• 
  74

  Soltanian, A.R., Mehdibarzi, D., Faghihzadeh, S., Naseri, M., Gerami, A.

  Mixture of Arnebia euchroma and Matricaria chamomilla (Marhame-Mafasel) for pain relief of osteoarthritis of the knee - A two-treatment, two-period crossover trial
  (2010) Archives of Medical Science, 6 (6), pp. 950-955. Cited 7 times.
  http://www.termedia.pl/Journal/-19/pdf-15987-210?filename=Mixture.pdf
  doi: 10.5114/aoms.2010.19307
  

  • View at Publisher
• 
  75

  Feißt, C., Franke, L., Appendino, G., Werz, O.

  Identification of molecular targets of the oligomeric nonprenylated acylphloroglucinols from Myrtus communis and their implication as anti-inflammatory compounds
  (2005) Journal of Pharmacology and Experimental Therapeutics, 315 (1), pp. 389-396. Cited 44 times.
  http://jpet.aspetjournals.org/cgi/reprint/315/1/389
  doi: 10.1124/jpet.105.090720
  

  • View at Publisher
• 
  76

  Maxia, A., Frau, M.A., Falconieri, D., Karchuli, M.S., Kasture, S.

  Essential oil of Myrtus communis inhibits inflammation in rats by reducing serum IL-6 and TNF-α
  (2011) Natural Product Communications, 6 (10), pp. 1545-1548. Cited 10 times.
  http://members.naturalproduct.us/Secure/ViewDoc.aspx?docId=4047
  
• 
  77

  Hosseinzadeh, H., Khoshdel, M., Ghorbani, M.

  Antinociceptive, Anti-inflammatory Effects and Acute Toxicity of Aqueous and Ethanolic Extracts of Myrtus communis L. Aerial Parts in Mice
  (2011) JAMS Journal of Acupuncture and Meridian Studies, 4 (4), pp. 242-247. Cited 20 times.
  doi: 10.1016/j.jams.2011.09.015
  

  • View at Publisher
• 
  78

  Ghannadi, A., Hajhashemi, V., Jafarabadi, H.

  An investigation of the analgesic and anti-inflammatory effects of Nigella sativa seed polyphenols
  (2005) Journal of Medicinal Food, 8 (4), pp. 488-493. Cited 68 times.
  doi: 10.1089/jmf.2005.8.488
  

  • View at Publisher
• 
  79

  Gheita, T.A., Kenawy, S.A.

  Effectiveness of Nigell sativ oil in the management of rheumatoid arthritis patients: Placebo controlled study
  (2012) Phytotherapy Research, 26 (8), pp. 1246-1248. Cited 19 times.
  doi: 10.1002/ptr.3679
  

  • View at Publisher
• 
  80

  Dang, G.K., Parekar, R.R., Kamat, S.K., Scindia, A.M., Rege, N.N.

  Antiinflammatory activity of Phyllanthus emblica, Plumbago zeylanica and Cyperus rotundus in acute models of inflammation
  (2011) Phytotherapy Research, 25 (6), pp. 904-908. Cited 22 times.
  doi: 10.1002/ptr.3345
  

  • View at Publisher

  Abdolghaffari, A.H.; Pharmacology and Applied Medicine Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj-Qazvin Freeway, Supa, Boulevard, Jahade-Daneshgahi Research Society, P.O Box: 141554364, Iran
© Copyright 2016 Elsevier B.V., All rights reserved.